Takahashi Ryotaro, Taguchi Noriko, Suzuki Masayuki, Cheng Xian Wu, Numaguchi Yasushi, Tsukamoto Hideto, Ikeda Nobuo, Murohara Toyoaki, Okumura Kenji
Department of Cardiology, Chunichi Hospital, Aichi, Japan.
Int Heart J. 2012;53(1):29-34. doi: 10.1536/ihj.53.29.
Since distinct cholesterol and triglyceride concentrations in major lipoproteins and their subclasses may be related to atherosclerosis, we investigated the relationship of cholesterol and triglyceride concentrations in lipoprotein subclasses and the severity of carotid intima-media thickness (IMT), a surrogate marker of subclinical atherosclerosis. We studied 116 apparently healthy Japanese men (53 ± 9 years) without a history of cardiovascular diseases who were not taking any medication. Carotid IMT was measured by means of high-resolution vascular ultrasound. Plasma cholesterol and triglyceride concentrations in major lipoproteins and their subclasses were determined by HPLC with gel permeation columns. By univariate analyses, carotid IMT was the most closely related to age (r = 0.528, P < 0.001), followed by smoking habit expressed as pack-year cigarette consumption (r = 0.409, P < 0.001). In addition to total cholesterol and LDL cholesterol, carotid IMT was significantly associated with cholesterol and triglyceride concentrations in several LDL and VLDL subclasses. Stepwise multiple linear regression analysis revealed that age (β = 0.436, P < 0.001), smoking (pack-years) (β = 0.225, P = 0.007), and large LDL cholesterol (β = 0.175, P = 0.023) were independent predictors of determining carotid IMT (adjusted R(2) = 0.347, P < 0.001). These results indicate that large LDL cholesterol is an important, independent determinant of carotid IMT in healthy men.
由于主要脂蛋白及其亚类中不同的胆固醇和甘油三酯浓度可能与动脉粥样硬化有关，我们研究了脂蛋白亚类中胆固醇和甘油三酯浓度与颈动脉内膜中层厚度（IMT）（亚临床动脉粥样硬化的替代标志物）严重程度之间的关系。我们研究了116名无心血管疾病史且未服用任何药物的表面健康的日本男性（53±9岁）。通过高分辨率血管超声测量颈动脉IMT。采用带有凝胶渗透柱的高效液相色谱法测定主要脂蛋白及其亚类中的血浆胆固醇和甘油三酯浓度。单因素分析显示，颈动脉IMT与年龄最密切相关（r = 0.528，P < 0.001），其次是按吸烟包年计算的吸烟习惯（r = 0.409，P < 0.001）。除总胆固醇和低密度脂蛋白胆固醇外，颈动脉IMT还与几个低密度脂蛋白和极低密度脂蛋白亚类中的胆固醇和甘油三酯浓度显著相关。逐步多元线性回归分析显示，年龄（β = 0.436，P < 0.001）、吸烟（包年）（β = 0.225，P = 0.007）和大颗粒低密度脂蛋白胆固醇（β = 0.175，P = 0.023）是决定颈动脉IMT的独立预测因素（调整后R(2)=0.347，P < 0.001）。这些结果表明，大颗粒低密度脂蛋白胆固醇是健康男性颈动脉IMT的重要独立决定因素。
