Department of Comprehensive General Internal Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan; Cardiovascular Nutrition Laboratory, Human Nutrition Research Center on Aging at Tufts University, and Tufts University School of Medicine, Boston, MA, United States; Department of General Internal Medicine, Kyushu Hospital, Fukuoka, Japan.
Department of General Internal Medicine, Kyushu Hospital, Fukuoka, Japan.
Clin Chim Acta. 2023 Aug 1;548:117521. doi: 10.1016/j.cca.2023.117521. Epub 2023 Aug 17.
The association between lipoprotein subclasses and carotid intima-media thickness (cIMT) progression has yet to be fully evaluated. We assessed which lipoprotein subclasses were associated with maximum cIMT levels in the general population.
In this study, cholesterol and triglyceride content of 20 lipoprotein subclasses were analyzed using gel permeation high-performance liquid chromatography (GP-HPLC) in 864 Japanese women and men (mean age 57 y, free of chronic liver or kidney diseases and off lipid-lowering, hormone replacement, or adrenocorticosteroid medications). Univariate and multivariate regression analyses and univariate and partial correlation analyses were performed to examine the relationships between lipoprotein subclasses and maximum cIMT levels.
After adjusting for age, sex, systolic blood pressure, smoking, diabetes, and anti-hypertensive agents, elevated low-density lipoprotein (LDL)-2 and -3 cholesterol (particle diameter 25.5 nm and 23.0 nm, respectively; medium and small LDL) were associated with higher maximum cIMT levels in both women and men (all p for trend < 0.05). These associations were significant even after participants taking anti-diabetic or anti-hypertensive agents were excluded. No significant associations were found between any triglyceride subclasses and maximum cIMT levels.
Smaller LDL particle cholesterol values are the most atherogenic lipoprotein parameter.
脂蛋白亚组分与颈动脉内膜中层厚度（cIMT）进展之间的关系尚未得到充分评估。我们评估了脂蛋白亚组分与一般人群中最大 cIMT 水平相关的情况。
本研究使用凝胶渗透高效液相色谱法（GP-HPLC）分析了 864 名日本男女（平均年龄 57 岁，无慢性肝脏或肾脏疾病，未服用降脂、激素替代或肾上腺皮质激素药物）的 20 种脂蛋白亚组分中的胆固醇和甘油三酯含量。进行单变量和多变量回归分析以及单变量和偏相关分析，以检查脂蛋白亚组分与最大 cIMT 水平之间的关系。
在校正年龄、性别、收缩压、吸烟、糖尿病和抗高血压药物后，升高的 LDL-2 和 -3 胆固醇（粒径分别为 25.5nm 和 23.0nm；中、小 LDL）与男女最大 cIMT 水平升高相关（所有趋势 p<0.05）。即使排除了服用抗糖尿病或抗高血压药物的参与者，这些关联仍然显著。任何甘油三酯亚组分与最大 cIMT 水平之间均无显著关联。
较小的 LDL 颗粒胆固醇值是最具动脉粥样硬化性的脂蛋白参数。
