Department of Radiation Oncology, The Ohio State University Medical Center, Stephanie Spielman Comprehensive Breast Center, Columbus, OH 43212, USA.
Int J Gynecol Cancer. 2012 May;22(4):703-8. doi: 10.1097/IGC.0b013e3182481611.
To describe the effects of intracavitary brachytherapy (IVB) on sexual function and quality of life of women with early-stage endometrial cancer.
Women with International Federation of Gynecology and Obstetrics stage I to stage II endometrial cancer treated surgically with or without IVB were identified and mailed questionnaires. Quality of life and sexual function were measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the cervical cancer disease-specific module. Pertinent data from prior surgery and radiation treatments were abstracted retrospectively. Linear transformation of the survey subscale scores was conducted per European Organization for Research and Treatment of Cancer guidelines.
Sixteen women in the IVB arm and 53 in the surgery-alone group completed the survey. Of the sexually active patients, 33% of the IVB patients and 42% of the surgery-alone patients felt their vagina was dry during sexual activity (P = 0.804) and 17% versus 20% felt their vagina was short (P = 0.884). Seventeen percent of patients in the IVB group felt their vagina was tight compared to 29% in the surgery-alone group (P = 0.891) and 0% versus 14% of patients reported pain during intercourse (P = 0.808). There was no statistically significant difference in sexual/vaginal functioning, sexual worry, or sexual enjoyment between the 2 groups.
Although both groups report vaginal changes that may affect sexual function, the patients treated with IVB reported similar outcomes on a sexual function questionnaire compared to patients treated with surgery alone.
描述腔内近距离放疗（IVB）对早期子宫内膜癌女性性功能和生活质量的影响。
确定接受国际妇产科联合会（FIGO）Ⅰ期至Ⅱ期子宫内膜癌手术治疗且联合或不联合 IVB 治疗的女性，并向其邮寄调查问卷。使用欧洲癌症研究与治疗组织（EORTC）生活质量问卷核心 30 项和宫颈癌专用模块来测量生活质量和性功能。回顾性地从先前的手术和放射治疗中提取相关数据。按照 EORTC 指南对调查子量表评分进行线性变换。
IVB 组有 16 名女性和手术组 53 名女性完成了调查。在有性生活的患者中，33%的 IVB 患者和 42%的手术组患者在性生活时感到阴道干燥（P=0.804），17%的 IVB 患者和 20%的手术组患者感到阴道短（P=0.884）。17%的 IVB 组患者感觉阴道紧，而手术组为 29%（P=0.891），0%的 IVB 组患者和 14%的手术组患者报告性交时疼痛（P=0.808）。两组在性/阴道功能、性担忧或性享受方面无统计学差异。
尽管两组患者均报告了可能影响性功能的阴道变化，但接受 IVB 治疗的患者在性功能问卷上的报告结果与单独接受手术治疗的患者相似。
