Krakowska Akademia Neurologii, Krakow, Poland.
J Neural Transm (Vienna). 2012 Nov;119(11):1361-5. doi: 10.1007/s00702-012-0787-x. Epub 2012 Mar 8.
The aim of this study was to identify determinants of functional disability, patient's quality of life (QoL) and caregivers' burden in Huntington's disease (HD). Eighty HD patients participated in the study. Motor and behavioral disturbances as well as cognitive impairment were assessed using motor, behavioral and cognitive parts of the Unified Huntington Disease Rating Scale (UHDRS); Hamilton Depression Rating Scale was used to assess depression. Disability, health-related QoL and the impact of the disease on the caregivers were assessed using the following methods: UHDRS Functional Assessment Score, SF-36 Scale and Caregiver Burden Inventory. Multiple regression analysis showed that motor disturbances, cognitive impairment, apathy and disease duration were the independent predictors of disability. Depression and cognitive disturbances were the determinants of patient's QoL, while motor disturbances and depression were the predictors of the caregiver burden. Patient's disability and QoL as well as caregivers' burden should be taken into consideration while planning treatment strategy and the results of the present study show that the predictors of those treatment targets are different.
本研究旨在确定亨廷顿病（HD）患者的功能障碍、生活质量（QoL）和照顾者负担的决定因素。80 名 HD 患者参与了研究。使用统一亨廷顿病评定量表（UHDRS）的运动、行为和认知部分评估运动和行为障碍以及认知障碍；使用汉密尔顿抑郁评定量表评估抑郁。使用以下方法评估残疾、与健康相关的 QoL 和疾病对照顾者的影响：UHDRS 功能评估评分、SF-36 量表和照顾者负担量表。多元回归分析表明，运动障碍、认知障碍、淡漠和疾病持续时间是残疾的独立预测因素。抑郁和认知障碍是患者 QoL 的决定因素，而运动障碍和抑郁是照顾者负担的预测因素。在制定治疗策略时应考虑患者的残疾和 QoL 以及照顾者的负担，本研究结果表明，这些治疗目标的预测因素不同。
