Research Center for Nutrition and Food Science, Technische Universität München, Freising, Germany.
Ann Nutr Metab. 2012;60(2):98-107. doi: 10.1159/000336177. Epub 2012 Mar 6.
Oral iron as a supplement has been associated with adverse health consequences, especially in the context of young children with active malaria. A potential aggravating role of non-transferrin-bound iron (NTBI) has been proposed.
NTBI responses in both a fasting and post-oral iron dosing situation were related to serum iron concentration and ferritin status. Fasting and 1, 2, and 3 h postdose serum samples were obtained in conjunction with oral ferrous sulfate supplementation in aqueous solution of 0, 15, 30, 60, 120 and 240 mg Fe in a cohort of 8 healthy Guatemalan men over a 9-week metabolic protocol. Hemoglobin, serum ferritin, percent transferrin saturation, serum iron and NTBI were all measured.
Circulating levels of serum iron and NTBI increased in a graded fashion in response to oral iron, with the relative increment for NTBI slightly greater than that of iron. Detectable NTBI was occasionally measured in fasting specimens, more frequently in subjects with high ferritin status. Post-iron NTBI responses, by contrast, were higher in normal-ferritin subjects in absolute terms, and rose with increasing postabsorptive serum iron responses.
The appearance and response of circulating NTBI were consistent with recognized principles of iron regulation.
口服铁补充剂与不良健康后果有关，尤其是在患有活动性疟疾的幼儿中。有人提出非转铁蛋白结合铁（NTBI）可能会加重病情。
在空腹和口服铁补充剂后，将 NTBI 反应与血清铁浓度和铁蛋白状态相关联。在一项为期 9 周的代谢方案中，8 名健康的危地马拉男性口服硫酸亚铁水溶液，剂量分别为 0、15、30、60、120 和 240mgFe，在空腹和口服后 1、2 和 3 小时采集血清样本，同时测量血红蛋白、血清铁蛋白、转铁蛋白饱和度、血清铁和 NTBI。
循环血清铁和 NTBI 水平呈梯度升高，口服铁后呈梯度升高，NTBI 的相对增量略高于铁。空腹标本偶尔会检测到 NTBI，在铁蛋白水平较高的患者中更常见。相比之下，在正常铁蛋白患者中，绝对铁后 NTBI 反应更高，并且随着吸收后血清铁反应的增加而增加。
循环 NTBI 的出现和反应符合铁调节的公认原则。
