Steele Shannon L, Kroeun Hou, Karakochuk Crystal D
Food, Nutrition and Health, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
British Columbia Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.
J Clin Med. 2019 Feb 3;8(2):180. doi: 10.3390/jcm8020180.
There is a lack of evidence for the safety of untargeted daily iron supplementation in women, especially in countries such as Cambodia, where both anemia and hemoglobinopathies are common. Our aim was to assess serum non-transferrin bound iron (NTBI), a toxic biochemical that accumulates in blood when too much iron is absorbed, in Cambodian women who received daily iron supplements in accordance with the 2016 global World Health Organization (WHO) guidelines. We used fasting venous blood samples that were collected in a 2015 supplementation trial among predominantly anemic Cambodian women (18⁻45 years). Serum NTBI was measured with use of the FeROS™ eLPI assay (Aferrix Ltd., Tel-Aviv, Israel) in randomly selected sub-groups of women who received 60 mg daily elemental iron as ferrous sulfate ( = 50) or a placebo ( = 50) for 12 weeks. Overall, = 17/100 (17%) of women had an elevated serum NTBI concentration (≥0.1 μmol/L) at 12 weeks; = 9 in the Fe group and = 8 in the placebo group. Elevated serum NTBI concentration was not associated with age, iron supplementation, transferrin saturation or severe hemoglobinopathies ( > 0.05). In this population of women with a high prevalence of hemoglobinopathies, we found that daily iron supplementation was not associated with elevated serum NTBI concentrations at 12 weeks, as compared to placebo.
对于未针对特定人群的每日补铁在女性中的安全性，缺乏相关证据，尤其是在柬埔寨等贫血和血红蛋白病都很常见的国家。我们的目的是评估血清非转铁蛋白结合铁（NTBI），这是一种有毒的生化物质，当吸收过多铁时会在血液中蓄积，在按照2016年全球世界卫生组织（WHO）指南每日接受铁补充剂的柬埔寨女性中进行评估。我们使用了2015年在主要为贫血的柬埔寨女性（18⁻45岁）中进行的一项补充试验中采集的空腹静脉血样本。在随机选择的接受60毫克每日元素铁硫酸亚铁（ = 50）或安慰剂（ = 50）为期12周的女性亚组中，使用FeROS™ eLPI检测法（Aferrix Ltd.，特拉维夫，以色列）测量血清NTBI。总体而言，100名女性中有17/100（17%）在12周时血清NTBI浓度升高（≥0.1微摩尔/升）；铁组中有9名，安慰剂组中有8名。血清NTBI浓度升高与年龄、铁补充剂、转铁蛋白饱和度或严重血红蛋白病无关（> 0.05）。在这个血红蛋白病患病率很高的女性人群中，我们发现与安慰剂相比，每日补铁在12周时与血清NTBI浓度升高无关。
