Andersson-Anvret M, Forsby N, Klein G, Henle W, Biörklund A
Int J Cancer. 1979 Jun 15;23(6):762-7. doi: 10.1002/ijc.2910230605.
In order to explore whether undifferentiated nasopharyngeal carcinoma (NPC) shows a regular association with Epstein-Barr virus (EBV), regardless of the geographical and ethnic origin of the patient, a correlated histopathological and nucleic acid hybridization study was performed on biopsies from Caucasian patients with nasopharyngeal carcinomas and from various controls. Among 12 undifferentiated NPCs, 11 were positive for EBV-DNA, with multiple copies of the viral genome per cell. Serological tests showed elevated anti-VCA and anti-EA(DA) titers. Six NPCs with various degrees of squamous differentiation, four malignant lymphomas of the nasopharynx and seven carcinomas located outside the nasopharynx were EBV-DNA negative. These findings further stress the uniqueness and regularity of the association between EBV-DNA and undifferentiated NPC. Clearly, the association extends over geographical barriers and holds true not only in the previously studied, moderate-incidence African ethnic group, but also in the low-incidence Western patients.
为了探究未分化鼻咽癌（NPC）是否与爱泼斯坦-巴尔病毒（EBV）存在规律关联，而不考虑患者的地理和种族来源，对白人鼻咽癌患者及各类对照的活检组织进行了相关的组织病理学和核酸杂交研究。在12例未分化鼻咽癌中，11例EBV-DNA呈阳性，每个细胞有多个病毒基因组拷贝。血清学检测显示抗VCA和抗EA(DA)滴度升高。6例不同程度鳞状分化的鼻咽癌、4例鼻咽部恶性淋巴瘤和7例鼻咽部以外的癌组织EBV-DNA均为阴性。这些发现进一步强调了EBV-DNA与未分化鼻咽癌之间关联的独特性和规律性。显然，这种关联跨越了地理障碍，不仅在先前研究的中等发病率的非洲种族群体中成立，在低发病率的西方患者中也成立。
