Glaser R, Nonoyama M, Szymanowski R T, Graham W
J Natl Cancer Inst. 1980 Jun;64(6):1317-9. doi: 10.1093/jnci/64.6.1317.
Nasopharyngeal carcinomas (NPC) from 2 black patients and 1 Caucasian patient were positive for Epstein-Barr virus (EBV) DNA. Of the tumors, 2 were lymphoepitheliomas (undifferentiated NPC) and 1 was a moderately differentiated NPC. All 3 patients had high IgG titers against EBV early antigen and high IgG and IgA titers against virus capsid antigen (VCA). In one patient, the levels of anti-VCA IgA were different than those of anti-VCA IgG over the course of the disease. Our data support the association of EBV and NPC in North America.
2名黑人患者和1名白人患者的鼻咽癌（NPC）的爱泼斯坦-巴尔病毒（EBV）DNA检测呈阳性。这些肿瘤中，2例为淋巴上皮瘤（未分化型NPC），1例为中度分化型NPC。所有3例患者针对EBV早期抗原的IgG滴度均较高，针对病毒衣壳抗原（VCA）的IgG和IgA滴度也较高。在1例患者中，疾病过程中抗VCA IgA的水平与抗VCA IgG的水平不同。我们的数据支持EBV与北美NPC之间的关联。
