Andersson-Anvret M, Klein G, Forsby N, Henle W
IARC Sci Publ (1971). 1978(20):347-57.
All of 51 undifferentiated carcinomas of the nasopharynx were EBV-DNA-positive and, in the few tests performed, EBNA-positive as well. Most of these patients also had high anti-EBV [VCA and EA (D)] antibody titres. Of four patients that had somewhat differentiated NPCs, two were EBV-DNA-positive with a corresponding serological picture, whereas two were negative with an EBV serology comparable to that of healthy donors. Of seven lymphomas localized in the nasopharynx, one was EBV-DNA-positive and corresponded histologically to Burkitt's lymphoma, whereas six others were EBV-DNA-negative. Fourteen head and neck carcinomas outside the nasopharynx were all EBV-DNA-negative. These results confirm the consistent and unique association of EBV DNA with undifferentiated carcinomas of the nasopharynx.
51例鼻咽未分化癌均为EBV - DNA阳性，且在少数检测中也为EBNA阳性。这些患者中的大多数抗EBV[VCA和EA(D)]抗体滴度也很高。4例有一定分化的鼻咽癌患者中，2例EBV - DNA阳性且血清学表现相应，而另外2例EBV血清学与健康供者相当，为阴性。7例鼻咽部淋巴瘤中，1例EBV - DNA阳性，组织学上符合伯基特淋巴瘤，而其他6例EBV - DNA阴性。14例鼻咽外的头颈部癌均为EBV - DNA阴性。这些结果证实了EBV DNA与鼻咽未分化癌之间始终如一的独特关联。
