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1
The quest for transplantation tolerance: have we finally sipped from the cup?探索移植耐受：我们是否终于如愿以偿？
Sci Transl Med. 2012 Mar 7;4(124):124fs5. doi: 10.1126/scitranslmed.3003678.
2
Cooking up tolerance: has a new recipe been created?炮制耐受性：创造出了新方法吗？
Am J Transplant. 2012 Jul;12(7):1667-9. doi: 10.1111/j.1600-6143.2012.04154.x. Epub 2012 Jun 15.
3
Use of hematopoietic cell transplants to achieve tolerance in patients with solid organ transplants.使用造血细胞移植使实体器官移植患者实现免疫耐受。
Blood. 2016 Mar 24;127(12):1539-43. doi: 10.1182/blood-2015-12-685107. Epub 2016 Jan 21.
4
Tolerance induction: hematopoietic chimerism.耐受诱导：造血嵌合。
Curr Opin Organ Transplant. 2013 Aug;18(4):402-7. doi: 10.1097/MOT.0b013e328363621d.
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Tolerance induction in HLA disparate living donor kidney transplantation by facilitating cell-enriched donor stem cell Infusion: The importance of durable chimerism.通过促进富含细胞的供体干细胞输注在 HLA 不相合活体供肾移植中诱导免疫耐受：持久嵌合体的重要性。
Hum Immunol. 2018 May;79(5):272-276. doi: 10.1016/j.humimm.2018.01.007. Epub 2018 Mar 2.
6
Negative response to noninherited maternal antigens confirmed by ELISA.通过酶联免疫吸附测定法确认对非遗传母体抗原的阴性反应。
Transplant Proc. 1999 Jun;31(4):1879-80. doi: 10.1016/s0041-1345(99)00196-7.
7
Megadose stem cell administration as a route to mixed chimerism.大剂量干细胞输注作为实现混合嵌合体的途径。
Curr Opin Organ Transplant. 2014 Aug;19(4):334-41. doi: 10.1097/MOT.0000000000000095.
8
[Feto-maternal immune tolerance and hematopoietic stem cell transplantation].[母胎免疫耐受与造血干细胞移植]
Nihon Naika Gakkai Zasshi. 2005 Jul 10;94(7):1362-8. doi: 10.2169/naika.94.1362.
9
Immune reconstitution/immunocompetence in recipients of kidney plus hematopoietic stem/facilitating cell transplants.肾移植联合造血干细胞/辅助细胞移植受者的免疫重建/免疫能力
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Embryonic stem cell derived and adult hematopoietic stem cell transplantation for tolerance induction in a renal allograft recipient:--a case report.胚胎干细胞衍生及成人造血干细胞移植用于诱导肾移植受者的免疫耐受：——病例报告
Transplant Proc. 2006 Nov;38(9):3103-8. doi: 10.1016/j.transproceed.2006.08.173.

引用本文的文献

1
The role of donor-derived veto cells in nonmyeloablative haploidentical HSCT.供体来源的否决细胞在非清髓性单倍型相合造血干细胞移植中的作用。
Bone Marrow Transplant. 2015 Jun;50 Suppl 2:S14-20. doi: 10.1038/bmt.2015.89.
2
Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts.针对血管化复合异体移植耐受性的免疫调节策略。
Transplantation. 2015 Aug;99(8):1590-1597. doi: 10.1097/TP.0000000000000681.
3
Transplantation tolerance and its outcome during infections and inflammation.感染和炎症期间的移植耐受及其结果。
Immunol Rev. 2014 Mar;258(1):80-101. doi: 10.1111/imr.12147.
4
Tolerance--is it worth it?宽容——这值得吗？
Cold Spring Harb Perspect Med. 2014 Feb 1;4(2):a015594. doi: 10.1101/cshperspect.a015594.
5
Historical overview of transplantation.移植的历史概述。
Cold Spring Harb Perspect Med. 2013 Apr 1;3(4):a014977. doi: 10.1101/cshperspect.a014977.
6
The need for inducing tolerance in vascularized composite allotransplantation.在血管化复合组织异体移植中诱导免疫耐受的必要性。
Clin Dev Immunol. 2012;2012:438078. doi: 10.1155/2012/438078. Epub 2012 Oct 31.
7
Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: durable chimerism predicts outcome.通过供者干细胞输注诱导 HLA 不相合活体供肾移植中的免疫耐受：持久的嵌合状态预测结局。
Transplantation. 2013 Jan 15;95(1):169-76. doi: 10.1097/TP.0b013e3182782fc1.
8
Evolving approaches of hematopoietic stem cell-based therapies to induce tolerance to organ transplants: the long road to tolerance.基于造血干细胞的治疗方法诱导对器官移植的耐受：通向耐受的漫长道路。
Clin Pharmacol Ther. 2013 Jan;93(1):36-45. doi: 10.1038/clpt.2012.201. Epub 2012 Oct 10.

本文引用的文献

1
Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation.在 HLA mismatched 联合肾和造血干细胞移植中无移植物抗宿主病或植入综合征的嵌合体和耐受。
Sci Transl Med. 2012 Mar 7;4(124):124ra28. doi: 10.1126/scitranslmed.3003509.
2
Long-term physiological side effects after allogeneic bone marrow transplantation.异基因骨髓移植后的长期生理副作用。
Hematology Am Soc Hematol Educ Program. 2010;2010:229-36. doi: 10.1182/asheducation-2010.1.229.
3
HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide.采用非清髓性预处理及大剂量移植后环磷酰胺的HLA单倍型相合骨髓移植治疗血液系统恶性肿瘤
Biol Blood Marrow Transplant. 2008 Jun;14(6):641-50. doi: 10.1016/j.bbmt.2008.03.005.
4
Tolerance and chimerism after renal and hematopoietic-cell transplantation.肾移植和造血细胞移植后的耐受性与嵌合现象。
N Engl J Med. 2008 Jan 24;358(4):362-8. doi: 10.1056/NEJMoa074191.
5
HLA-mismatched renal transplantation without maintenance immunosuppression.无维持免疫抑制的HLA错配肾移植
N Engl J Med. 2008 Jan 24;358(4):353-61. doi: 10.1056/NEJMoa071074.
6
Actively acquired tolerance of foreign cells.对外源细胞的主动获得性耐受。
Nature. 1953 Oct 3;172(4379):603-6. doi: 10.1038/172603a0.
7
Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model.在大型动物模型中使用非清髓性预处理方案实现稳定的混合嵌合状态和免疫耐受。
J Clin Invest. 2000 Jan;105(2):173-81. doi: 10.1172/JCI7913.
8
Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts.用同基因加异基因或异种骨髓进行重建可导致对同种异体移植物或异种移植物的特异性接受。
Nature. 1984;307(5947):168-70. doi: 10.1038/307168a0.
9
Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen.非致死性预处理方案诱导的混合嵌合状态与永久性特异性移植耐受
J Exp Med. 1989 Feb 1;169(2):493-502. doi: 10.1084/jem.169.2.493.
10
Immunologic tolerance to renal allografts after bone marrow transplants from the same donors.来自相同供体的骨髓移植后对肾同种异体移植物的免疫耐受。
Ann Intern Med. 1991 Jun 1;114(11):954-5. doi: 10.7326/0003-4819-114-11-954.

探索移植耐受：我们是否终于如愿以偿？

The quest for transplantation tolerance: have we finally sipped from the cup?

机构信息

Massachusetts General Hospital, Boston, MA 02114, USA.

出版信息

Sci Transl Med. 2012 Mar 7;4(124):124fs5. doi: 10.1126/scitranslmed.3003678.

DOI:10.1126/scitranslmed.3003678
PMID:22399262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3951288/
Abstract

New advances in achieving hematopoietic chimerism may facilitate immunological tolerance to kidney transplants.

摘要

在实现造血嵌合方面的新进展可能有助于对肾移植的免疫耐受。