探索移植耐受：我们是否终于如愿以偿？
The quest for transplantation tolerance: have we finally sipped from the cup?
机构信息
Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Sci Transl Med. 2012 Mar 7;4(124):124fs5. doi: 10.1126/scitranslmed.3003678.
Abstract
New advances in achieving hematopoietic chimerism may facilitate immunological tolerance to kidney transplants.
摘要
在实现造血嵌合方面的新进展可能有助于对肾移植的免疫耐受。
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Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation.在 HLA mismatched 联合肾和造血干细胞移植中无移植物抗宿主病或植入综合征的嵌合体和耐受。
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HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide.采用非清髓性预处理及大剂量移植后环磷酰胺的HLA单倍型相合骨髓移植治疗血液系统恶性肿瘤
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HLA-mismatched renal transplantation without maintenance immunosuppression.无维持免疫抑制的HLA错配肾移植
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Actively acquired tolerance of foreign cells.对外源细胞的主动获得性耐受。
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Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts.用同基因加异基因或异种骨髓进行重建可导致对同种异体移植物或异种移植物的特异性接受。
Nature. 1984;307(5947):168-70. doi: 10.1038/307168a0.
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Immunologic tolerance to renal allografts after bone marrow transplants from the same donors.来自相同供体的骨髓移植后对肾同种异体移植物的免疫耐受。
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