José Carreras Center for Immunotherapy and Gene Therapy, Saarland University Medical Center, Homburg, Saar, Germany.
Adv Exp Med Biol. 2012;739:252-61. doi: 10.1007/978-1-4614-1704-0_16.
Since healthy aging remains one of the ideals of modern society, both, the identification of the underlying molecular mechanisms and interventions regarding the aging process are of considerable interest. Among the mechanisms currently being considered, the sirtuin family of histone deacetylases have been implicated to play a crucial role during the aging process both due to their requirement of NAD(+) as a cofactor for enzymatic activity, which determines a crucial link between sirtuins and the energy dependent regulation of gene transcription and their versatile target substrates mainly consisting of key regulators of metabolic, stress and cell cycle control. This chapter summarizes current evidences linking sirtuins to aging and outlines their potential as promising therapeutic targets for the treatment of age-related diseases.
由于健康老龄化仍然是现代社会的理想之一，因此，鉴定潜在的分子机制和干预衰老过程都具有相当大的意义。在目前正在研究的机制中，组蛋白去乙酰化酶的 sirtuin 家族由于其酶活性需要 NAD(+)作为辅助因子，因此在衰老过程中发挥着至关重要的作用，这决定了 sirtuins 与能量依赖性基因转录调控以及它们主要由代谢、应激和细胞周期控制的关键调节剂组成的广泛的靶底物之间的关键联系。本章总结了将 sirtuins 与衰老联系起来的现有证据，并概述了它们作为治疗与年龄相关疾病的有希望的治疗靶点的潜力。
