Qadir Muhammad Imran, Anwar Sidra
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
Crit Rev Eukaryot Gene Expr. 2017;27(4):321-329. doi: 10.1615/CritRevEukaryotGeneExpr.2017019532.
The many ways of aging have been and continue to be investigated. For this reason, over many years, several studies have resolved some of the genetic details underlying aging processes. It resulted in the identification of a yeast gene known as Sir2, which is a longevity modulator. Sir2 and SIRT1 are the mammalian homologs of yeast genes. Sirtuins (including SIRT1) play an important role in aging of the brain and the metabolic regulation pathway in mammals. Aging in the brain is caused by the loss of neurophysiologic functions due to neurodegeneration. The sirtuin family plays a central role in the beneficial effects of calorie restriction (CR). CR is linked with an increase in life span and decrease in the risk of diseases related to the brain. Sirtuins may be helpful for us in studying the process of aging and treatment of diseases related with aging.
衰老的多种方式一直并仍在被研究。因此，多年来，多项研究解析了一些衰老过程背后的遗传细节。这导致了一种名为Sir2的酵母基因的发现，它是一种寿命调节因子。Sir2和SIRT1是酵母基因的哺乳动物同源物。沉默调节蛋白（包括SIRT1）在哺乳动物大脑衰老和代谢调节途径中发挥重要作用。大脑衰老由神经退行性变导致神经生理功能丧失引起。沉默调节蛋白家族在热量限制（CR）的有益作用中起核心作用。CR与寿命延长以及与大脑相关疾病风险降低有关。沉默调节蛋白可能有助于我们研究衰老过程以及治疗与衰老相关的疾病。
