新基因的起源与进化。

The origin and evolution of new genes.

作者信息

Cardoso-Moreira Margarida, Long Manyuan

机构信息

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.

出版信息

Methods Mol Biol. 2012;856:161-86. doi: 10.1007/978-1-61779-585-5_7.

DOI:10.1007/978-1-61779-585-5_7

PMID:22399459

Abstract

New genes are a major source of genetic innovation in genomes. However, until recently, understanding how new genes originate and how they evolve was hampered by the lack of appropriate genetic datasets. The advent of the genomic era brought about a revolution in the amount of data available to study new genes. For the first time, decades-old theoretical principles could be tested empirically and novel and unexpected avenues of research opened up. This chapter explores how genomic data can and is being used to study both the origin and evolution of new genes and the surprising discoveries made thus far.

摘要

新基因是基因组中遗传创新的主要来源。然而，直到最近，由于缺乏合适的遗传数据集，了解新基因如何起源以及如何进化受到了阻碍。基因组时代的到来给研究新基因可用的数据量带来了一场革命。几十年来的理论原则首次能够通过实证进行检验，新的、意想不到的研究途径也随之开启。本章探讨了基因组数据如何以及正在被用于研究新基因的起源和进化，以及迄今为止所取得的惊人发现。