Schmitt J K
Department of Veterans Affairs Medical Center, Richmond, Virginia.
Am J Med Sci. 1990 Sep;300(3):144-7. doi: 10.1097/00000441-199009000-00003.
In seven normal volunteers, the basal and arginine-stimulated levels of plasma growth hormone, glucose, glucagon, and free fatty acids and serum insulin was determined during placebo and during indomethacin 25 mg four times daily. Basal plasma growth hormone was higher during indomethacin (5.4 +/- 1 vs 1.7 +/- 2 ng/ml, p less than 0.005), as was the mean integrated response to intravenous arginine (40 +/- 14 vs 6 +/- 4 ng.min/ml, p less than 0.05). Despite lack of effect on plasma glucagon, indomethacin decreased the insulin response to arginine. The fall in free fatty acids during arginine infusion was decreased by indomethacin, which may in part be due to increased plasma growth hormone levels. In view of the many patients treated with indomethacin, the effect on growth hormone may be of clinical importance.
在7名正常志愿者中，测定了安慰剂期和每日4次服用25毫克吲哚美辛期间血浆生长激素、葡萄糖、胰高血糖素、游离脂肪酸的基础水平和精氨酸刺激水平以及血清胰岛素水平。吲哚美辛治疗期间基础血浆生长激素水平较高（5.4±1 vs 1.7±2纳克/毫升，p<0.005），静脉注射精氨酸的平均综合反应也是如此（40±14 vs 6±4纳克·分钟/毫升，p<0.05）。尽管吲哚美辛对血浆胰高血糖素无影响，但它降低了对精氨酸的胰岛素反应。吲哚美辛减少了精氨酸输注期间游离脂肪酸的下降，这可能部分归因于血浆生长激素水平升高。鉴于有许多患者使用吲哚美辛治疗，其对生长激素的影响可能具有临床重要性。
