Giugliano D, Luyckx A S, Lefebvre P J
Diabete Metab. 1980 Mar;6(1):39-46.
This study aimed at evaluating the effect of acetylsalicylic acid (ASA) on blood glucose, plasma FFA, glycerol, 3-hydroxybutyrate, alanine, C-peptide, glucagon and growth hormone responses to arginine in subjects with insulin-dependent diabetes. For this purpose, seven insulin-requiring diabetics were submitted to a standard arginine tolerance test before and after a three day treatment with ASA (50 mg/kg/daily, plus 1 g before the second test). ASA treatment resulted in no significant changes in either basal or arginine-stimulated blood glucose, but it significantly decreased the basal concentrations of plasma FFA (p less than 0.05), 3-hydroxybutyrate (p less than 0.05) and glycerol (p less than 0.05). In addition, the fall in plasma FFA concentrations during arginine infusion was significantly less after ASA than levels observed without ASA (--262 +/- 100 microEq/l vs --35 +/- 57 microEq/l, p less than 0.02). No significant changes in either basal or arginine-stimulated glucagon concentrations were observed after ASA; by contrast, the growth hormone peak was significantly reduced after ASA (11.3 +/- 4.2 ng/ml vs 5.1 +/- 1.1 ng/ml, p less than 0.05). These metabolic effects exerted by ASA in insulin-dependent diabetes seem not to be related to alterations in endogenously secreted insulin since C-peptide circulating levels were similar during the pre- and post-treatment arginine tests.
本研究旨在评估乙酰水杨酸（ASA）对胰岛素依赖型糖尿病患者血糖、血浆游离脂肪酸（FFA）、甘油、3-羟基丁酸、丙氨酸、C肽、胰高血糖素以及精氨酸刺激后生长激素反应的影响。为此，七名需要胰岛素治疗的糖尿病患者在接受为期三天的ASA治疗（50毫克/千克/日，第二次检测前额外加服1克）前后，分别接受了标准的精氨酸耐量试验。ASA治疗后，基础血糖或精氨酸刺激后的血糖均无显著变化，但血浆FFA（p<0.05）、3-羟基丁酸（p<0.05）和甘油（p<0.05）的基础浓度显著降低。此外，精氨酸输注期间血浆FFA浓度的下降幅度在ASA治疗后显著低于未使用ASA时的水平（-262±100微当量/升对-35±57微当量/升，p<0.02）。ASA治疗后，基础或精氨酸刺激后的胰高血糖素浓度均无显著变化；相比之下，ASA治疗后生长激素峰值显著降低（11.3±4.2纳克/毫升对5.1±1.1纳克/毫升，p<0.05）。ASA在胰岛素依赖型糖尿病中产生的这些代谢效应似乎与内源性分泌胰岛素的改变无关，因为治疗前后精氨酸试验期间循环C肽水平相似。
