Pernet Alain, Petriccioli Nicole
Unité de diabétologie, Service de médecine interne, Hôpital de la Tour, 1217 Meyrin.
Rev Med Suisse. 2011 Nov 16;7(317):2236-8.
The increasing prevalence of obesity and diabetes represents one of the major public health problem in developed countries, leading to intensive research on the causes and intervention possibilities. Over the last years, intestinal flora became a first-line topic in this research: the development of techniques in molecular biology allowed a more specific approach and the elaboration of a genetic library of the intestinal microbiota. This article summarises acquired knowledge and hypothesis related to the potential role of intestinal microbiota in the development of obesity and insulin resistance.
肥胖症和糖尿病患病率的不断上升是发达国家主要的公共卫生问题之一，这引发了对其病因及干预可能性的深入研究。在过去几年中，肠道菌群已成为该研究中的一个首要课题：分子生物学技术的发展使得研究方法更为具体，也促成了肠道微生物群遗传文库的建立。本文总结了与肠道微生物群在肥胖症和胰岛素抵抗发展过程中的潜在作用相关的已有知识和假说。
