Yue Tongtao, Zhang Xianren
Division of Molecular and Materials Simulation, State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China.
Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jan;85(1 Pt 1):011917. doi: 10.1103/PhysRevE.85.011917. Epub 2012 Jan 27.
One key question in signal transduction is how the signal is relayed from the outer leaflet of a cellular membrane to the inner leaflet. Using a simulation model, a mechanism for the mediation of signal transduction is proposed here in which the coupling between membrane proteins in different leaflets can be achieved by the clustering of anchored proteins, without recruiting transmembrane proteins. Depending on the hydrophobic length of the anchored proteins, three coupling patterns, including face-to-face clustering, interdigitated clustering, and weak-coupled clustering, are observed in this work. This observation provides a possible explanation of how a particular downstream signaling pathway is selected.
信号转导中的一个关键问题是信号如何从细胞膜的外小叶传递到内小叶。本文利用一个模拟模型提出了一种信号转导介导机制，其中不同小叶中的膜蛋白之间的偶联可以通过锚定蛋白的聚集来实现，而无需招募跨膜蛋白。根据锚定蛋白的疏水长度，在这项研究中观察到三种偶联模式，包括面对面聚集、叉指状聚集和弱偶联聚集。这一观察结果为如何选择特定的下游信号通路提供了一种可能的解释。
