Simons K, Ikonen E
Nature. 1997 Jun 5;387(6633):569-72. doi: 10.1038/42408.
A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
基于鞘脂和胆固醇的动态聚集形成在流体双层中移动的筏,提出了细胞膜结构的一个新方面。有人提出,当膜在细胞内移动以及在信号转导过程中,这些筏作为蛋白质附着的平台发挥作用。