Department of Pediatrics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
J Palliat Med. 2012 Jun;15(6):719-22. doi: 10.1089/jpm.2011.0097. Epub 2012 Mar 8.
For difficult to treat neuropathic pain from cancer, adjuvant analgesics are often used with opioids. We present the case of a 5-year-old girl who was diagnosed with meningitis caused by malignant T-cell lymphoma. She had severe neuropathic pain not relieved by increasing doses of a fentanyl infusion. Intravenous administration of ketamine and lidocaine in combination with fentanyl provided excellent analgesia without significant side effects. Ketamine and lidocaine can be safely infused together with concomitant opioids for the treatment of refractory neuropathic pain caused by cancer.
对于癌症引起的难以治疗的神经性疼痛，常采用辅助镇痛剂与阿片类药物联合治疗。我们报告了 1 例 5 岁女孩，因恶性 T 细胞淋巴瘤导致脑膜炎，她患有严重的神经性疼痛，增加芬太尼输注剂量也无法缓解。静脉给予氯胺酮和利多卡因联合芬太尼可提供良好的镇痛效果，且无明显副作用。氯胺酮和利多卡因可与阿片类药物同时安全输注，用于治疗癌症引起的难治性神经性疼痛。
