Moutran R, Maatouk I, Wehbé J, Abadjian G, Obeid G
Service de dermatologie, Hôtel-Dieu de France, BP 16-6830, Achrafieh, Beyrouth, Liban.
Ann Dermatol Venereol. 2012 Mar;139(3):204-8. doi: 10.1016/j.annder.2011.12.019. Epub 2012 Jan 30.
S. dimidiatum (recently reclassified as N. dimidiatum) is a fungus that causes nail and/or superficial skin infection. It may also cause subcutaneous and deep infection, chiefly in immunocompromised patients.
An 87-year-old male treated with oral corticosteroids for sarcoidosis consulted for violaceous cutaneous nodules on the back of his hands. Histopathological examination revealed epithelioid cell granulomas with numerous mycelial filaments and multiple spores. Culture of a biopsy sample resulted in growth of numerous colonies of S. dimidiatum and the patient was treated with intravenous amphotericin B.
This organism is transmitted by direct or indirect contact with contaminated soil or plants. It mainly causes superficial skin and nail infections, and may result in deeper infections on rare occasions. We report a case of subcutaneous infection with S. dimidiatum in an immunocompromised patient (due to general steroid therapy) that was successfully treated using amphotericin B.
双间柱顶孢菌（最近重新分类为间柱顶孢菌）是一种可引起指甲和/或浅表皮肤感染的真菌。它也可能引起皮下和深部感染，主要发生在免疫功能低下的患者中。
一名87岁男性因结节病接受口服皮质类固醇治疗，因手背出现紫红色皮肤结节前来咨询。组织病理学检查显示上皮样细胞肉芽肿，伴有大量菌丝和多个孢子。活检样本培养出大量双间柱顶孢菌菌落，患者接受了静脉注射两性霉素B治疗。
这种病原体通过直接或间接接触受污染的土壤或植物传播。它主要引起浅表皮肤和指甲感染，偶尔也可能导致更深层的感染。我们报告了一例免疫功能低下患者（由于全身类固醇治疗）发生的间柱顶孢菌皮下感染病例，该病例使用两性霉素B成功治愈。
