Ljungqvist O, Boija P O, Esahili H, Larsson M, Ware J
Department of Surgery, Karolinska Hospital and Institute, Stockholm, Sweden.
Am J Physiol. 1990 Nov;259(5 Pt 1):E692-8. doi: 10.1152/ajpendo.1990.259.5.E692.
Liver glycogen content, blood glucose, insulin, glucagon, and epinephrine were determined during 1 h hemorrhagic hypotension at 60 mmHg and 23 h thereafter in fed and two groups of 24-h food-deprived rats receiving either no infusion or 30% glucose intravenously during hemorrhage. Liver glycogen content was reduced by greater than 90% after 24-h food deprivation. Fed and food-deprived rats given glucose developed similar and substantial elevations of blood glucose during hemorrhage, whereas changes in blood glucose were modest in food-deprived rats given no infusion. In fed rats, liver glycogen was reduced by 60% during the 1-h bleed, but within 2 h after hemorrhage repletion of liver glycogen content commenced. By 6 h, approximately 75% of the glycogen lost during hemorrhage had been restored, and 23 h after hemorrhage liver glycogen content was six times greater compared with nonbled controls. Although glycogen levels increased after hemorrhage in food-deprived animals, the increase was negligible compared with that found in fed rats. Infusion of glucose during hemorrhage or adrenergic blockade after hemorrhage did not alter glycogen repletion in food-deprived rats. Posthemorrhage fed animals had high levels of insulin, glucagon, and epinephrine during hemorrhage, whereas insulin levels remained low in food-deprived rats despite exogenously induced hyperglycemia. It is concluded that rapid and substantial glycogen repletion can occur even immediately poststress. The conditions seem to be related to the nutritional state at the time of the insult.
在血压为60 mmHg的1小时失血性低血压期间以及此后23小时，测定了喂食大鼠和两组24小时禁食大鼠的肝糖原含量、血糖、胰岛素、胰高血糖素和肾上腺素水平。这两组禁食大鼠在出血期间，一组不进行输液，另一组静脉输注30%葡萄糖。24小时禁食后，肝糖原含量降低了90%以上。在出血期间，输注葡萄糖的喂食大鼠和禁食大鼠的血糖都出现了相似且显著的升高，而未进行输液的禁食大鼠血糖变化不大。在喂食大鼠中，1小时出血期间肝糖原减少了60%，但出血后2小时内肝糖原含量开始恢复。到6小时时，出血期间损失的糖原约75%已得到恢复，出血后23小时，肝糖原含量比未出血的对照组高6倍。尽管禁食动物出血后糖原水平有所升高，但与喂食大鼠相比，升高幅度可忽略不计。出血期间输注葡萄糖或出血后进行肾上腺素能阻断，均未改变禁食大鼠的糖原恢复情况。出血后，喂食动物在出血期间胰岛素、胰高血糖素和肾上腺素水平较高，而禁食大鼠尽管外源诱导血糖升高，但胰岛素水平仍较低。结论是，即使在应激后立即也能迅速且大量地恢复糖原。这些情况似乎与损伤时的营养状态有关。
