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一种新的机制,解释了急性 B 型主动脉夹层主要变得复杂、变得更复杂或保持不复杂的原因。

A new mechanism by which an acute type B aortic dissection is primarily complicated, becomes complicated, or remains uncomplicated.

机构信息

Department of Cardiovascular and Interventional Radiology, Medical University of Vienna, Vienna Austria.

出版信息

Ann Thorac Surg. 2012 Apr;93(4):1215-22. doi: 10.1016/j.athoracsur.2011.12.020. Epub 2012 Mar 7.

DOI:10.1016/j.athoracsur.2011.12.020
PMID:22402280
Abstract

BACKGROUND

This study is to evaluate if different locations of the primary entry tear result in primary complicated, secondary complicated, or uncomplicated acute type B aortic dissection.

METHODS

Sixty-five patients were analyzed. Patients were stratified according to the location of the primary entry tear. Primary entry tears in axial computed tomographic scans at the upper circumference (180°) of the distal aortic arch were defined as convex (group A) and the remaining as concave (group B). Detailed morphometry was done and the clinical outcome, including need for thoracic endovascular aortic repair, was evaluated.

RESULTS

Forty-two patients (group A) had the primary entry tear at the convexity and 23 patients (group B) had the primary entry tear at the concavity of the distal aortic arch. There was a significant difference with regard to the incidence of primary complicated type B aortic dissection (group A 21% vs group B 61%, p = 0.003) and with regard to the development of complications in group A (9 days; 9 to 37) versus group B (0 days; 0 to 13, p = 0.03). Cox regression analysis revealed a primary entry tear at the concavity to be the only independent predictor of primary or secondary development of a complicated acute type B aortic dissection (hazard ratio, 1.8; 95% confidence interval, 1.0 to 3.2).

CONCLUSIONS

A primary entry tear at the concavity of the distal aortic arch is associated with a significant increase of the occurrence of complicated acute type B aortic dissection. Due to low procedural risk and high success rates, closure of the primary entry tear with thoracic endovascular aortic repair is strongly recommended in this newly defined high-risk subgroup of patients.

摘要

背景

本研究旨在评估原发破口的不同位置是否会导致原发性复杂型、继发性复杂型或非复杂型急性 B 型主动脉夹层。

方法

共分析了 65 例患者。根据原发破口的位置对患者进行分层。轴向 CT 扫描中,位于升主动脉远端上 180°的原发破口定义为凸面(A 组),其余为凹面(B 组)。对其进行详细的形态学测量,并评估其临床结果,包括是否需要胸主动脉腔内修复术。

结果

42 例患者(A 组)的原发破口位于凸面,23 例患者(B 组)的原发破口位于升主动脉远端的凹面。A 组原发性复杂型 B 型主动脉夹层的发生率(21%比 61%,p=0.003)和 A 组并发症的发展情况(9 天;9-37 天)与 B 组(0 天;0-13 天,p=0.03)之间存在显著差异。Cox 回归分析显示,原发破口位于凹面是原发性或继发性复杂急性 B 型主动脉夹层发展的唯一独立预测因素(风险比,1.8;95%置信区间,1.0-3.2)。

结论

升主动脉远端凹面的原发破口与复杂急性 B 型主动脉夹层的发生率显著增加相关。由于手术风险低、成功率高,强烈推荐在这一新定义的高危亚组患者中,使用胸主动脉腔内修复术来封闭原发破口。

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