Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7445, USA.
Nutr Clin Pract. 2012 Apr;27(2):226-34. doi: 10.1177/0884533612439895. Epub 2012 Mar 8.
The intestinal microbiota is a functional organ with a variety of important metabolic, trophic, immunologic, and digestive activities. Current data suggest that alterations in the intestinal microbiota may be related to disease conditions. Manipulation of the intestinal microbiota such as with probiotics, prebiotics, and synbiotics may be beneficial in preventing and treating certain disease conditions. This article provides an overview of the evidence gathered through randomized clinical trials, reviews, and meta-analyses on probiotics and prebiotics in commonly studied conditions in the pediatric population. It concludes with current recommendations for their use, noting safety and gaps in clinical evidence.
肠道微生物群是一个具有多种重要代谢、营养、免疫和消化功能的器官。目前的数据表明，肠道微生物群的改变可能与疾病状况有关。通过益生菌、益生元和合生元等方法来操纵肠道微生物群可能有助于预防和治疗某些疾病。本文通过随机临床试验、综述和荟萃分析，对益生菌和益生元在儿科常见疾病中的应用进行了综述。本文最后提出了目前对其使用的建议，同时指出了临床证据中的安全性和差距。
