Taira Masato
Department of Cognitive Neurobiology, Tokyo Medical and Dental University, Tokyo, Japan.
Brain Nerve. 2012 Mar;64(3):263-71.
To examine the neural basis of navigation we recorded the activity of neurons in the monkey medial parietal region (MPR) while monkeys actively navigated through a virtual environment. We found navigation neurons whose responses to the same movement at the same location were modulated depending on the route that the monkey was currently taking, that is, in a route-selective manner. The reversible inactivation of MPR neurons by muscimol resulted in a monkey becoming lost during the navigation task trial. These results suggest that MPR plays a critical role in navigation by integrating location information and self-movement information.
为了研究导航的神经基础，我们记录了猴子在虚拟环境中主动导航时内侧顶叶区域（MPR）神经元的活动。我们发现，导航神经元对同一位置的相同运动的反应会根据猴子当前所走的路线进行调制，即以路线选择性的方式。用蝇蕈醇对MPR神经元进行可逆性失活，导致猴子在导航任务试验中迷路。这些结果表明，MPR通过整合位置信息和自我运动信息在导航中起着关键作用。
