Feng Y, Busch S, Gretz N, Hoffmann S, Hammes H-P
Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, University of Heidelberg, Germany.
Exp Clin Endocrinol Diabetes. 2012 Apr;120(4):199-201. doi: 10.1055/s-0032-1304571. Epub 2012 Mar 8.
Diabetic retinopathy shares important features with neurodegenerative retinal diseases, including loss of ganglion cells and retinal thinning. The impact on vasoregression and subsequent ischemia-driven changes such as macular edema and proliferative retinopathy are not established. Studies using adult neurodegenerative animal models such as the transgenic TGR(CMV-PKD2(1/703)HA) rat imply early activation of the innate immunity system and the complement system as well as microglia playing a role in the damage of the retinal neurovascular unit.
糖尿病视网膜病变与神经退行性视网膜疾病具有重要的共同特征，包括神经节细胞丢失和视网膜变薄。其对血管消退以及随后由缺血驱动的变化（如黄斑水肿和增殖性视网膜病变）的影响尚未明确。使用成年神经退行性动物模型（如转基因TGR(CMV-PKD2(1/703)HA)大鼠）进行的研究表明，先天免疫系统和补体系统的早期激活以及小胶质细胞在视网膜神经血管单元损伤中发挥作用。
