抗氧化剂对糖尿病视网膜病变影响的最新进展：体外实验、动物研究及临床试验
Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials.
作者信息
Garcia-Medina Jose Javier, Rubio-Velazquez Elena, Foulquie-Moreno Elisa, Casaroli-Marano Ricardo P, Pinazo-Duran Maria Dolores, Zanon-Moreno Vicente, Del-Rio-Vellosillo Monica
机构信息
Department of Ophthalmology, General University Hospital Morales Meseguer, 30007 Murcia, Spain.
Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, Spain.
出版信息
Antioxidants (Basel). 2020 Jun 26;9(6):561. doi: 10.3390/antiox9060561.
Abstract
Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. Nonetheless, these techniques have not been demonstrated to completely stop the evolution of this disorder. The pathophysiology of DR is not fully known, but there is more and more evidence indicating that oxidative stress is an important mechanism in the progression of DR. In this sense, antioxidants have been suggested as a possible therapy to reduce the complications of DR. In this review we aim to assemble updated information in relation to in vitro experiments, animal studies and clinical trials dealing with the effect of the antioxidants on DR.
摘要
糖尿病视网膜病变（DR）的现有治疗方法包括控制血糖和血压、玻璃体切除术、光凝治疗以及玻璃体内注射抗血管内皮生长因子或皮质类固醇。然而，这些技术尚未被证明能完全阻止这种疾病的发展。DR的病理生理学尚未完全明确，但越来越多的证据表明氧化应激是DR进展的重要机制。从这个意义上说，抗氧化剂已被提议作为一种可能的疗法来减少DR的并发症。在本综述中，我们旨在收集有关抗氧化剂对DR影响的体外实验、动物研究和临床试验的最新信息。
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2
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