Division of Hematology/Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, 3-35, Michishita-cho, Nakamura-ku, Nagoya, Aichi, 453-8511, Japan.
Int J Hematol. 2012 May;95(5):577-80. doi: 10.1007/s12185-012-1044-7. Epub 2012 Mar 9.
Acute myeloid leukemia with abnormal bone marrow eosinophilia (AML-M4Eo) is often reported in core binding factor (CBF) leukemia, with translocations such as inv(16)(p13q22), t(16;16)(p13;q22) or t(8;21)(q22;q22); however, it is rarely reported with t(16;21)(q24;q22), which produces the RUNX1-CBFA2T3 (AML1-MTG16) chimera. The similarity between this chimera and RUNX1-RUNXT1 (AML1-MTG8) by t(8;21)(q22;q22) remains controversial. Adult leukemia with t(16;21)(q24;q22) was primarily therapy related, and shows poor prognosis; however, pediatric AML with this translocation was quite rare and tended to be de novo AML. We present here a 4-year-old boy with de novo AML-M4Eo and t(16;21)(q24;q22). He received chemotherapy and survived for more than 70 months without transplantation. We speculated that pediatric AML with t(16;21)(q24;q22) showed favorable prognosis, as with t(8;21)(q22;q22).
伴有骨髓嗜酸粒细胞增多的急性髓系白血病（AML-M4Eo）常发生于核心结合因子（CBF）白血病，伴有易位如 inv(16)(p13q22)、t(16;16)(p13;q22) 或 t(8;21)(q22;q22)；然而，伴有 t(16;21)(q24;q22) 的情况很少见，其产生 RUNX1-CBFA2T3（AML1-MTG16）嵌合体。这种嵌合体与 t(8;21)(q22;q22) 产生的 RUNX1-RUNXT1（AML1-MTG8）之间的相似性仍存在争议。成人伴有 t(16;21)(q24;q22) 的白血病主要与治疗相关，预后不良；然而，儿童伴有这种易位的 AML 非常罕见，往往是初发的 AML。我们在此介绍一例 4 岁男性初发 AML-M4Eo 伴 t(16;21)(q24;q22)。他接受了化疗，在没有移植的情况下存活了 70 多个月。我们推测，伴有 t(16;21)(q24;q22) 的儿童 AML 预后良好，与 t(8;21)(q22;q22) 相似。
