急性髓细胞性白血病复发时出现明显的骨髓嗜酸性粒细胞增多，并伴有t(12;20)(q24;q11)易位。
Marked bone marrow eosinophilia at the time of relapse of acute myeloblastic leukaemia in association with the appearance of translocation t(12;20)(q24;q11).
作者信息
Partridge F, Richardson W, Kearns P, Wilcox R, Majumdar G
机构信息
Haematology Department, George Eliot Hospital, Nuneaton, England.
出版信息
Leuk Lymphoma. 1996 Jun;22(1-2):181-2. doi: 10.3109/10428199609051747.
We report a case of acute myeloblastic leukaemia (AML), FAB type M2, with karyotype t(8;21)(q22;q22), who at the time of relapse showed marked eosinophilia of the bone marrow. Karyotype analysis showed the appearance of an additional clone t(8;21)(q22;q22),t(12;20)(q24;q11). To the best of our knowledge, marked eosinophilia has not been reported in association with this particular chromosomal translocation.
我们报告一例急性髓细胞白血病（AML），FAB分型为M2，核型为t(8;21)(q22;q22)，该患者复发时骨髓出现明显嗜酸性粒细胞增多。核型分析显示出现了一个额外的克隆t(8;21)(q22;q22)，t(12;20)(q24;q11)。据我们所知，尚未有与这种特定染色体易位相关的明显嗜酸性粒细胞增多的报道。
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