金属伴侣蛋白：治疗阿尔茨海默病的整体方法。
Metal chaperones: a holistic approach to the treatment of Alzheimer's disease.
作者信息
Adlard Paul Anthony, Bush Ashley Ian
机构信息
The Mental Health Research Institute, University of Melbourne Parkville, VIC, Australia.
出版信息
Front Psychiatry. 2012 Mar 2;3:15. doi: 10.3389/fpsyt.2012.00015. eCollection 2012.
Abstract
As evidence for the role of metal ion dysregulation in the pathogenesis of multiple CNS disorders grows, it has become important to more precisely identify and differentiate the biological effects of various pharmacological modulators of metal ion homeostasis. This is particularly evident in disorders such as Alzheimer's disease (AD), where the use of metal chaperones (that transport metals), as opposed to chelators (which exclude metals from biological interactions), may prove to be the first truly disease modifying approach for this condition. The purpose of this mini-review is to highlight the emerging notion that metal chaperones, such as PBT2 (Prana Biotechnology), modulate a variety of critical pathways affecting key aspects of the AD cascade to provide a more "holistic" approach to the treatment of this disease.
摘要
随着金属离子失调在多种中枢神经系统疾病发病机制中的作用证据不断增加，更精确地识别和区分各种金属离子稳态药理调节剂的生物学效应变得至关重要。这在阿尔茨海默病（AD）等疾病中尤为明显，与螯合剂（将金属排除在生物相互作用之外）不同，使用金属伴侣蛋白（运输金属）可能被证明是针对这种疾病的第一种真正的疾病修饰方法。本综述的目的是强调一个新出现的观点，即金属伴侣蛋白，如PBT2（普拉纳生物技术公司），可调节影响AD级联反应关键方面的多种关键途径，从而为该疾病的治疗提供一种更“全面”的方法。
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