Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH/NIMH, Bethesda, MD.
Sci Rep. 2012;2:308. doi: 10.1038/srep00308. Epub 2012 Mar 8.
Individuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses to physiological stressors. Using [(15)O-H(2)O] positron emission tomography we assessed whether the regional cerebral blood flow (rCBF) response to arterial cannulation differed between patients with MDD and healthy controls (HCs). Fifty-one MDD patients and 62 HCs were scanned following arterial cannulation and 15 MDD patients and 17 HCs were scanned without arterial cannulation. A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD. A whole brain analysis showed increased rCBF of the right post-central gyrus, left temporopolar cortex, and right amygdala during arterial cannulation in MDD patients. The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.
患有重度抑郁症（MDD）的个体对心理压力表现出异常的神经生理反应，但对其对生理应激源的神经生理反应知之甚少。使用 [(15)O-H(2)O] 正电子发射断层扫描，我们评估了 MDD 患者和健康对照者（HCs）在动脉插管后的局部脑血流（rCBF）反应是否存在差异。在动脉插管后对 51 名 MDD 患者和 62 名 HCs 进行扫描，对 15 名 MDD 患者和 17 名 HCs 进行无动脉插管扫描。感兴趣区分析显示，MDD 患者动脉插管后前扣带回皮质和右侧杏仁核的 rCBF 明显增加。全脑分析显示，MDD 患者在动脉插管期间右侧后中央回、左侧颞极皮质和右侧杏仁核的 rCBF 增加。右侧杏仁核的 rCBF 与抑郁严重程度显著相关。可以想象，MDD 患者对侵入性身体应激的边缘反应大于 HCs。
