在印度南部一线高效抗逆转录病毒治疗失败的患者中，1型人类免疫缺陷病毒C亚型逆转录酶第67和69密码子处出现异常插入和缺失：与其他耐药突变的关联
Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing South Indian patients: association with other resistance mutations.
作者信息
Saravanan Shanmugam, Madhavan Vidya, Kantor Rami, Sivamalar Sathasivam, Gomathi Selvamurthi, Solomon Sunil S, Kumarasamy Nagalingeswaran, Smith Davey M, Schooley Robert T, Solomon Suniti, Balakrishnan Pachamuthu
机构信息
YRG CARE, Chennai, India.
出版信息
AIDS Res Hum Retroviruses. 2012 Dec;28(12):1763-5. doi: 10.1089/AID.2011.0331. Epub 2012 May 21.
Abstract
We report a high frequency of drug resistance mutations among patients with unusual insertions or deletions at the β(3)-β(4) hairpin-loop-coding region of HIV-1 subtype C reverse transcriptase, during failure of first-line antiretroviral therapy containing only reverse transcriptase inhibitors in Chennai, India.
摘要
在印度金奈仅含逆转录酶抑制剂的一线抗逆转录病毒治疗失败期间，我们报告了HIV-1 C亚型逆转录酶β(3)-β(4)发夹环编码区存在异常插入或缺失的患者中耐药突变的高频率。
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本文引用的文献
1
Update of the drug resistance mutations in HIV-1: December 2010.2010年12月HIV-1耐药性突变的更新情况。
Top HIV Med. 2010 Dec;18(5):156-63.
2
Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel.成人 HIV 感染的抗逆转录病毒治疗：国际艾滋病协会-美国小组 2010 年的建议。
JAMA. 2010 Jul 21;304(3):321-33. doi: 10.1001/jama.2010.1004.
3
Patients infected with HIV type 1 subtype CRF01_AE and failing first-line nevirapine- and efavirenz-based regimens demonstrate considerable cross-resistance to etravirine.感染1型艾滋病病毒CRF01_AE亚型且一线奈韦拉平与依非韦伦治疗方案失败的患者，对依曲韦林表现出显著的交叉耐药性。
AIDS Res Hum Retroviruses. 2010 Jun;26(6):609-11. doi: 10.1089/aid.2009.0107.
4
Evaluation of two human immunodeficiency virus-1 genotyping systems: ViroSeq 2.0 and an in-house method.两种人类免疫缺陷病毒1型基因分型系统的评估：ViroSeq 2.0和一种内部方法。
J Virol Methods. 2009 Aug;159(2):211-6. doi: 10.1016/j.jviromet.2009.03.021. Epub 2009 Apr 2.
5
Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel.成人HIV-1感染的抗逆转录病毒药物耐药性检测：美国国际艾滋病协会专家组2008年建议
Clin Infect Dis. 2008 Jul 15;47(2):266-85. doi: 10.1086/589297.
6
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7
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