Chen C, Akanay-Diesel S, Schuster F R, Klee D, Schmidt K G, Donner B C
Department of Pediatric Cardiology and Pneumology, University Düsseldorf, Düsseldorf, Germany.
Pediatr Transplant. 2012 Nov;16(7):E320-4. doi: 10.1111/j.1399-3046.2012.01673.x. Epub 2012 Mar 9.
PTLD is a serious and frequently observed complication after solid organ transplantation. We present a six-yr-old girl with a rapidly growing, solid tumor of the lip four yr after orthotopic heart transplantation, which was classified as monomorphic PTLD with the characteristics of a diffuse large B-cell lymphoma. Treatment with reduction in immunosuppression, ganciclovir, and anti B-cell monoclonal antibody (rituximab) resulted in full remission since 12 months. To the best of our knowledge, this report is the first description of PTLD in the lip in a pediatric patient after heart transplantation in the English literature.
移植后淋巴组织增生性疾病（PTLD）是实体器官移植后一种严重且常见的并发症。我们报告了一名6岁女童，在原位心脏移植4年后唇部出现一个快速生长的实性肿瘤，该肿瘤被分类为具有弥漫性大B细胞淋巴瘤特征的单形性PTLD。通过减少免疫抑制、使用更昔洛韦和抗B细胞单克隆抗体（利妥昔单抗）进行治疗，12个月后实现了完全缓解。据我们所知，本报告是英文文献中首例关于心脏移植后儿科患者唇部PTLD的描述。
