Department of General Biology, Institute of Biological Sciences, Federal University of Goiás , Goiânia, Goiás, Brazil.
J Med Food. 2012 Jun;15(6):563-7. doi: 10.1089/jmf.2011.0270. Epub 2012 Mar 9.
Eugenia dysenterica DC. (Myrtaceae), popularly known in Brazil as cagaiteira, is a widespread plant species in the Brazilian Cerrado. In folk medicine, the leaves of this plant are used to treat diarrhea and dysentery. The fruits are used for fresh consumption and industrial purposes. Because of the use of this plant as a therapeutic resource and food, the present study evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of the lyophilized ethanolic leaf extract of E. dysenterica using the mouse bone marrow micronucleus test. The genotoxicity and antigenotoxicity of this extract were evaluated using the frequency of micronucleated polychromatic erythrocytes, and the cytotoxicity and anticytotoxicity were assessed by the polychromatic and normochromatic erythrocyte ratio. According to our results, the lyophilized ethanolic leaf extract of E. dysenterica exhibited genotoxic and cytotoxic effects at the higher doses and protection against cyclophosphamide-induced genotoxic and cytotoxic actions at all doses tested.
大齿酸酸豆（Myrtaceae），俗称巴西苦樱桃，是巴西塞拉多广泛分布的植物物种。在民间医学中，该植物的叶子被用于治疗腹泻和痢疾。其果实可用于新鲜食用和工业用途。鉴于该植物被用作治疗资源和食物，本研究采用小鼠骨髓微核试验，评估了冻干乙醇叶提取物对 Eugenia dysenterica 的遗传毒性、细胞毒性、抗原毒性和抗细胞毒性作用。该提取物的遗传毒性和抗原毒性通过微核多染红细胞的频率来评估，细胞毒性和抗细胞毒性则通过多染性和正常红细胞的比例来评估。根据我们的结果，Eugenia dysenterica 的冻干乙醇叶提取物在较高剂量下表现出遗传毒性和细胞毒性作用，并且在所有测试剂量下都能防止环磷酰胺引起的遗传毒性和细胞毒性作用。
