蛋白酪氨酸磷酸酶对瘦素抵抗的调节作用。
Modulation of leptin resistance by protein tyrosine phosphatases.
机构信息
Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.
出版信息
Cell Metab. 2012 Mar 7;15(3):292-7. doi: 10.1016/j.cmet.2012.02.004.
PMID:22405067
Abstract
Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling.
摘要
瘦素通过抑制食物摄入和增加能量消耗在体重控制中起着核心作用。瘦素抵抗的概念的出现是为了解释肥胖症中瘦素水平升高似乎矛盾的现象。最近的发现表明，蛋白酪氨酸磷酸酶通过全局抑制瘦素信号通路，成为瘦素抵抗的关键因素。
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