The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33014 Tampere, Finland.
Natural Resources Institute Finland, Bioeconomy and Environment, 96200 Rovaniemi, Finland.
Nutrients. 2021 Oct 21;13(11):3693. doi: 10.3390/nu13113693.
The prevalence of nonalcoholic fatty liver disease (NAFLD) is growing worldwide in association with Western-style diet and increasing obesity. Lingonberry ( L.) is rich in polyphenols and has been shown to attenuate adverse metabolic changes in obese liver. This paper investigated the effects of lingonberry supplementation on hepatic gene expression in high-fat diet induced obesity in a mouse model. C57BL/6N male mice were fed for six weeks with either a high-fat (HF) or low-fat (LF) diet (46% and 10% energy from fat, respectively) or HF diet supplemented with air-dried lingonberry powder (HF + LGB). HF diet induced a major phenotypic change in the liver, predominantly affecting genes involved in inflammation and in glucose and lipid metabolism. Lingonberry supplementation prevented the effect of HF diet on an array of genes (in total on 263 genes) associated particularly with lipid or glucose metabolic process (such as , , ), inflammatory/immune response or cell migration (such as , , , , , ) and cell cycle regulation (such as , , ). The present results suggest that lingonberry supplementation prevents HF diet-induced adverse changes in the liver that are known to predispose the development of NAFLD and its comorbidities. The findings encourage carrying out human intervention trials to confirm the results, with the aim of recommending the use of lingonberries as a part of healthy diet against obesity and its hepatic and metabolic comorbidities.
非酒精性脂肪性肝病（NAFLD）的患病率在全球范围内与西方饮食和肥胖的增加有关。越橘富含多酚，已被证明可减轻肥胖肝脏的不良代谢变化。本文研究了越橘补充剂对高脂肪饮食诱导肥胖小鼠模型中肝脏基因表达的影响。C57BL/6N 雄性小鼠分别用高脂肪（HF）或低脂肪（LF）饮食（分别提供 46%和 10%的能量来自脂肪）或 HF 饮食补充风干越橘粉（HF + LGB）喂养六周。HF 饮食主要影响参与炎症以及葡萄糖和脂质代谢的基因，导致肝脏发生重大表型变化。越橘补充剂可预防 HF 饮食对与脂质或葡萄糖代谢过程（如、、）、炎症/免疫反应或细胞迁移（如、、、、、）和细胞周期调节（如、、）相关的一系列基因（总共 263 个基因）的影响。本研究结果表明，越橘补充剂可预防 HF 饮食引起的肝脏不良变化，已知这些变化易导致 NAFLD 及其合并症的发生。这些发现鼓励进行人体干预试验以确认结果，并旨在推荐将越橘作为健康饮食的一部分，以预防肥胖及其肝脏和代谢合并症。
