Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
Schizophr Res. 2012 May;137(1-3):212-8. doi: 10.1016/j.schres.2012.02.017. Epub 2012 Mar 8.
Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated, little is known about social cognitive deficits in this regard. This study investigated the influence of social cognition on QOL in schizophrenia. A sample of 1032 patients, 1011 of their siblings, and 552 healthy controls was recruited from the Dutch Genetic Risk and Outcome in Psychosis (GROUP) study. Participants completed a battery of cognitive tests, including social cognitive tests on theory of mind and emotion perception. To assess QOL the World Health Organization QOL Assessment-BREF (WHOQOL-BREF) was used. Schizophrenia symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Social cognitive performance was significantly worse in patients compared to siblings and healthy controls. Patients had the poorest QOL, while QOL in healthy controls was better than in siblings. Theory of mind but not emotion perception or neurocognition was associated with QOL in patients, whereas neurocognition was the only significant predictor of QOL in siblings and healthy controls. There was a significant interaction between theory of mind and symptom severity with respect to QOL. Our study indicates that social cognition is associated with QOL in schizophrenia. Theory of mind rather than emotion perception is associated with QOL, and this association is moderated by schizophrenia symptoms. In particular, patients with relatively unimpaired theory of mind and more severe schizophrenia symptoms have poor QOL and could therefore benefit from therapeutic intervention.
精神分裂症与生活质量（QOL）较差有关。尽管神经认知缺陷和精神病理学对精神分裂症患者 QOL 的影响最近已经阐明，但在这方面，社会认知缺陷知之甚少。本研究调查了社会认知对精神分裂症患者 QOL 的影响。从荷兰遗传风险和精神分裂症结局研究（GROUP）中招募了 1032 名患者、1011 名患者的兄弟姐妹和 552 名健康对照者。参与者完成了一系列认知测试，包括心理理论和情绪感知的社会认知测试。为了评估 QOL，使用了世界卫生组织生活质量评估简表（WHOQOL-BREF）。采用阳性和阴性症状量表（PANSS）评估精神分裂症症状。与兄弟姐妹和健康对照组相比，患者的社会认知表现明显较差。患者的 QOL 最差，而健康对照组的 QOL 优于兄弟姐妹。心理理论，但不是情绪感知或神经认知与患者的 QOL 相关，而神经认知是兄弟姐妹和健康对照组 QOL 的唯一显著预测因素。心理理论与症状严重程度对 QOL 的交互作用具有统计学意义。我们的研究表明，社会认知与精神分裂症的 QOL 有关。心理理论而不是情绪感知与 QOL 相关，这种关联受精神分裂症症状的调节。特别是，具有相对未受损的心理理论和更严重的精神分裂症症状的患者 QOL 较差，因此可以从治疗干预中受益。
