The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, No.5 Ankang Lane, Dewai Avenue, Xicheng District, Beijing, 100088, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
BMC Psychiatry. 2023 Oct 31;23(1):793. doi: 10.1186/s12888-023-05303-9.
This is a cross-sectional study comparing the degree of subjective quality of life (QOL) impairment and its predictive factors in first-episode schizophrenia (FES) and individuals at clinical high-risk (CHR) for psychosis.
Seventy-seven FES, 59 CHR, and 64 healthy controls (HC) were included. The QOL of all participants was assessed using the World Health Organization Quality of Life (WHOQOL)-Brief Form (BREF). Psychiatric symptoms of individuals with FES were assessed with the Positive and Negative Syndrome Scale (PANSS), five factors were further identified through factor analysis; for individuals with CHR and HC, the Scale of Prodromal Symptoms (SOPS) was used.
The total and four sub-domain scores of the WHOQOL-BREF in the FES and CHR groups were lower than those of the HC group. The overall and psychological health scores in the CHR group were lowest. In the FES group, after applying Bonferroni's correction, there is a negative correlation between the total QOL scores and anxiety/depressive symptom scores (r = -0.34, P = 0.003). The stepwise multiple regression analysis showed that the QOL of both FES and CHR group were negatively affected by anxiety/depressive symptoms and unemployment (P < 0.05).
Compared with FES, CHR individuals are more dissatisfied with their QOL. Although diagnostic assessment of FES and CHR relies heavily on positive symptoms, the QOL is more affected by anxiety/depressive symptoms and social functioning.
这是一项横断面研究，比较了首发精神分裂症（FES）和精神病高危（CHR）个体主观生活质量（QOL）受损的程度及其预测因素。
纳入 77 例 FES、59 例 CHR 和 64 例健康对照者（HC）。所有参与者的 QOL 均采用世界卫生组织生活质量（WHOQOL）-简明量表（BREF）进行评估。FES 个体的精神症状采用阳性和阴性综合征量表（PANSS）评估，通过因子分析进一步确定 5 个因子；CHR 和 HC 个体采用前驱症状量表（SOPS）。
FES 和 CHR 组的 WHOQOL-BREF 总分和四个子量表评分均低于 HC 组。CHR 组的总体和心理健康评分最低。在 FES 组中，经 Bonferroni 校正后，QOL 总分与焦虑/抑郁症状评分呈负相关（r=-0.34，P=0.003）。逐步多元回归分析显示，FES 和 CHR 组的 QOL 均受焦虑/抑郁症状和失业的负面影响（P<0.05）。
与 FES 相比，CHR 个体对 QOL 的满意度更低。尽管 FES 和 CHR 的诊断评估主要依赖于阳性症状，但 QOL 更受焦虑/抑郁症状和社会功能的影响。
