Saif Muhammad Wasif, Ng John, Chang Bryan, Russo Suzanne
Columbia University College of Physicians and Surgeons, New York, NY, USA.
JOP. 2012 Mar 10;13(2):174-6.
Pancreatic neuroendocrine tumors (PNET) represent a heterogeneous group of tumors with varying tumor biology and prognosis. Advanced PNETs remain a difficult therapeutic challenge because of their high malignant potential and their resistance to conventional chemotherapy although there have been recent developments with promising results with the use of novel agents for the treatment of this disease. Combined modality chemoradiation is not widely used in the management of locally advanced pancreatic endocrine tumors. We discuss Abstract #335 from 2012 ASCO GI Cancers Symposium and share our experience to discuss efficacy and toxicity of concurrent capecitabine or infusional 5-fluorouracil and radiotherapy in patients with resected, locally advanced and metastatic PNET. Prospective studies to investigate the role of radiation and chemoradiation are warranted.
胰腺神经内分泌肿瘤（PNET）是一组异质性肿瘤，具有不同的肿瘤生物学特性和预后。晚期PNET仍然是一个棘手的治疗难题，因为它们具有很高的恶性潜能且对传统化疗耐药，尽管最近使用新型药物治疗该疾病取得了有前景的结果。联合放化疗在局部晚期胰腺内分泌肿瘤的治疗中并未广泛应用。我们讨论了2012年美国临床肿瘤学会（ASCO）胃肠道癌症研讨会的摘要#335，并分享我们的经验，以探讨在接受手术切除、局部晚期和转移性PNET患者中，同时使用卡培他滨或持续输注5-氟尿嘧啶与放疗的疗效和毒性。有必要开展前瞻性研究来探究放疗和放化疗的作用。
