Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
Onco Targets Ther. 2013 Jun 17;6:707-11. doi: 10.2147/OTT.S45889. Print 2013.
Primary primitive neuroectodermal tumors (PNETs) are rare and high-grade malignant tumors that mostly occur in children and young adults. The most common sites are the trunk, limbs, and retroperitoneum. Herein, we present a case of a PNET involving the cervix uteri in a 27-year-old woman. The lesion showed characteristic histologic features of a PNET and was positive for the immunohistochemical markers cluster of differentiation (CD) 99, vimentin, neuron-specific enolase, neural cell adhesion molecule 1 (CD56), and CD117 (c-kit), further defining the tumor while helping to confirm PNET. The clinical Stage IIIB tumor was treated with chemotherapy and radiotherapy.
原始神经外胚层肿瘤（PNET）是一种罕见的高度恶性肿瘤，主要发生在儿童和青少年。最常见的部位是躯干、四肢和腹膜后。本文报道了 1 例发生于 27 岁女性宫颈的 PNET 病例。病变具有 PNET 的特征性组织学特征，免疫组织化学标志物 CD99、波形蛋白、神经元特异性烯醇化酶、神经细胞黏附分子 1（CD56）和 CD117（c-kit）阳性，进一步明确了肿瘤，有助于确认 PNET。该临床分期为 IIIB 期肿瘤，采用化疗和放疗治疗。
