Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan.
Neuropsychologia. 2012 Jun;50(7):1514-20. doi: 10.1016/j.neuropsychologia.2012.03.004. Epub 2012 Mar 8.
This study investigates the distinct patterns of local and long-range gamma oscillations between patients with bipolar disorder (BD) and major depressive disorder (MDD). Twenty BD patients, twenty MDD patients, and twenty normal controls participated in this study. For each participant, the event-related magnetoencephalographic responses while performing an implicit emotional task were recorded and processed with time-frequency analysis. Compared to normal controls, the BD patients exhibited the gamma power decease at the right frontal and prefrontal regions and yet gamma power increase at the right posterior temporal region. The abnormal long-range gamma oscillation between the right frontal and parietal-occipital region was also found. These results indicate that the BD patients may have hyperactivity in perceptual binding of emotional features and tend to be oversensitive to facial features. On the other hand, MDD patients displayed increased early gamma activity at the left anterior temporal region, which may imply their hyperactivated binding process of emotional features at corticolimbic regions. The distinct alterations of gamma patterns between the BD and MDD patients implicate that their impairments of binding processes are located at different regions. Gamma activity in the parietal and left posterior temporal regions may be a potential index to differentiate BD patients from MDD patients.
本研究旨在探究双相情感障碍（BD）和重度抑郁症（MDD）患者局部和远距离伽马振荡的独特模式。二十名 BD 患者、二十名 MDD 患者和二十名正常对照参与了这项研究。对于每个参与者，在执行隐式情绪任务时记录并通过时频分析处理事件相关的脑磁图响应。与正常对照组相比，BD 患者表现出右侧额区和前额区伽马功率下降，而右侧颞后区伽马功率增加。还发现了右侧额区和顶枕区之间异常的远距离伽马振荡。这些结果表明，BD 患者可能在情绪特征的感知绑定中过度活跃，并且对面部特征过于敏感。另一方面，MDD 患者在左侧前颞区显示出早期伽马活动增加，这可能意味着他们在边缘皮质区域的情绪特征的绑定过程过度活跃。BD 和 MDD 患者之间伽马模式的明显改变表明，他们的绑定过程受损位于不同的区域。顶区和左侧后颞区的伽马活动可能是区分 BD 患者和 MDD 患者的潜在指标。
