Liu T Y, Chen Y S, Su T P, Hsieh J C, Chen L F
Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan ; Integrated Brain Research Unit, Division of Clinical Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Department of Computer Science, National Chiao Tung University, Hsinchu 300, Taiwan.
Biomed Res Int. 2014;2014:906104. doi: 10.1155/2014/906104. Epub 2014 Mar 13.
This study investigates the cortical abnormalities of early emotion perception in patients with major depressive disorder (MDD) and bipolar disorder (BD) using gamma oscillations. Twenty-three MDD patients, twenty-five BD patients, and twenty-four normal controls were enrolled and their event-related magnetoencephalographic responses were recorded during implicit emotional tasks. Our results demonstrated abnormal gamma activity within 100 ms in the emotion-related regions (amygdala, orbitofrontal (OFC) cortex, anterior insula (AI), and superior temporal pole) in the MDD patients, suggesting that these patients may have dysfunctions or negativity biases in perceptual binding of emotional features at very early stage. Decreased left superior medial frontal cortex (smFC) responses to happy faces in the MDD patients were correlated with their serious level of depression symptoms, indicating that decreased smFC activity perhaps underlies irregular positive emotion processing in depressed patients. In the BD patients, we showed abnormal activation in visual regions (inferior/middle occipital and middle temporal cortices) which responded to emotional faces within 100 ms, supporting that the BD patients may hyperactively respond to emotional features in perceptual binding. The discriminant function of gamma activation in the left smFC, right medial OFC, right AI/inferior OFC, and the right precentral cortex accurately classified 89.6% of patients as unipolar/bipolar disorders.
本研究利用伽马振荡研究重度抑郁症（MDD）和双相情感障碍（BD）患者早期情绪感知的皮质异常。招募了23名MDD患者、25名BD患者和24名正常对照者，并在隐性情绪任务期间记录他们的事件相关脑磁图反应。我们的结果表明，MDD患者在与情绪相关的区域（杏仁核、眶额皮质（OFC）、前岛叶（AI）和颞极上部）内100毫秒内的伽马活动异常，这表明这些患者在非常早期的情绪特征感知结合方面可能存在功能障碍或消极偏差。MDD患者左侧额上内侧皮质（smFC）对快乐面孔的反应降低与其抑郁症状的严重程度相关，这表明smFC活动降低可能是抑郁症患者异常积极情绪处理的基础。在BD患者中，我们发现视觉区域（枕下/枕中皮质和颞中皮质）在100毫秒内对情绪面孔有异常激活，这支持BD患者在感知结合中可能对情绪特征过度活跃地做出反应。左侧smFC、右侧内侧OFC、右侧AI/眶额皮质下部和右侧中央前皮质中伽马激活的判别函数准确地将89.6%的患者分类为单相/双相情感障碍。
