比较胆钙化醇和骨化三醇对中国维生素 D 不足的绝经后妇女钙代谢和骨转换的影响。
Comparison of the effects of cholecalciferol and calcitriol on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency.
机构信息
Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, China.
出版信息
Acta Pharmacol Sin. 2012 Apr;33(4):490-5. doi: 10.1038/aps.2011.172. Epub 2012 Mar 12.
AIM
To compare the effects of cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency.
METHODS
One hundred Chinese postmenopausal women aged 63.8±7.0 years and with serum 25-hydroxyvitamin D [25(OH)D] concentration <30 ng/mL were recruited. The subjects were divided into 2 groups based on the age and serum 25(OH)D concentration: 50 subjects (group A) received cholecalciferol (800 IU/d), and 50 subjects (group B) received calcitriol (0.25 μg/d) for 3 months. In addition, all the subjects received Caltrate D (calcium plus 125 IU cholecalciferol) daily in the form of one pill. The markers of calcium metabolism and bone turnover, including the serum levels of calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25(OH)D and β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX), were measured before and after the intervention.
RESULTS
After the 3-month intervention, the serum 25(OH)D concentration in group A was significantly increased from 16.01 ± 5.0 to 20.02 ± 4.5 ng/mL, while that in group B had no significant change. The serum calcium levels in both the groups were significantly increased (group A: from 2.36 ± 0.1 to 2.45 ± 0.1 mmol/L; group B: from 2.36 ± 0.1 to 2.44 ± 0.1 mmol/L). The levels of serum intact parathyroid hormone in both the groups were significantly decreased (group A: from 48.56 ± 12.8 to 39.59 ± 12.6 pg/mL; group B: from 53.67 ± 20.0 to 40.32 ± 15.4 pg/mL). The serum levels of β-CTX in both the groups were also significantly decreased (group A: from 373.93 ± 135.3 to 325.04 ± 149.0 ng/L; group B: from 431.00 ± 137.1 to 371.74 ± 185.0 ng/L).
CONCLUSION
We concluded that both cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) plus Caltrate D modifies the serum calcium and bone turnover markers in Chinese postmenopausal women with vitamin D insufficiency. In addition, cholecalciferol (800 IU/d) significantly increased the serum 25(OH)D concentration.
目的
比较胆钙化醇（800IU/d）和骨化三醇（0.25μg/d）对中国维生素 D 不足的绝经后妇女钙代谢和骨转换的影响。
方法
招募了 100 名年龄 63.8±7.0 岁、血清 25-羟维生素 D [25(OH)D]浓度<30ng/mL 的中国绝经后妇女。根据年龄和血清 25(OH)D 浓度将受试者分为 2 组：50 名受试者（A 组）接受胆钙化醇（800IU/d），50 名受试者（B 组）接受骨化三醇（0.25μg/d），持续 3 个月。此外，所有受试者均每日服用 1 片钙尔奇 D（钙加 125IU 胆钙化醇）。干预前后测定钙代谢和骨转换标志物，包括血清钙、磷、碱性磷酸酶、全段甲状旁腺激素、25(OH)D 和 I 型胶原β交联 C 端肽（β-CTX）。
结果
干预 3 个月后，A 组血清 25(OH)D 浓度从 16.01±5.0ng/mL 显著升高至 20.02±4.5ng/mL，而 B 组无显著变化。两组血清钙水平均显著升高（A 组：从 2.36±0.1mmol/L 升高至 2.45±0.1mmol/L；B 组：从 2.36±0.1mmol/L 升高至 2.44±0.1mmol/L）。两组血清全段甲状旁腺激素水平均显著降低（A 组：从 48.56±12.8pg/mL 降低至 39.59±12.6pg/mL；B 组：从 53.67±20.0pg/mL 降低至 40.32±15.4pg/mL）。两组血清β-CTX 水平也均显著降低（A 组：从 373.93±135.3ng/L 降低至 325.04±149.0ng/L；B 组：从 431.00±137.1ng/L 降低至 371.74±185.0ng/L）。
结论
我们得出结论，胆钙化醇（800IU/d）和骨化三醇（0.25μg/d）加钙尔奇 D 均可改变中国维生素 D 不足的绝经后妇女的血清钙和骨转换标志物。此外，胆钙化醇（800IU/d）可显著提高血清 25(OH)D 浓度。
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