Downes Noel
Sequani Limited, Ledbury, Herefordshire, UK.
Toxicol Pathol. 2012 Jul;40(5):830-7. doi: 10.1177/0192623312439124. Epub 2012 Mar 9.
The recent increase in numbers of juvenile toxicity studies over the past few years has doubtless added to our knowledge of the development of organ systems in the young rodent, but it is perhaps rather more difficult to answer the questions as to whether this body of work has served us well in terms of assessing risk in the pediatric population. If there are shortcomings, are they the result of poor study design or poor sensitivity of the model, or are the wrong questions being posed? This article provides a superficial overview of the progress made thus far and considers which aspects of study design and model choice currently fail to adequately address the major issues surrounding pediatric toxicology.
在过去几年中，幼年毒性研究的数量最近有所增加，这无疑增加了我们对幼龄啮齿动物器官系统发育的了解，但要回答这项工作在评估儿科人群风险方面是否对我们有很大帮助的问题，可能就比较困难了。如果存在不足，是研究设计不佳还是模型敏感性不足导致的，抑或是提出了错误的问题？本文对迄今为止取得的进展进行了简要概述，并思考了研究设计和模型选择的哪些方面目前未能充分解决围绕儿科毒理学的主要问题。
