University of Nigeria, Nsukka, Enugu, Nigeria.
Qual Life Res. 2013 Mar;22(2):455-8. doi: 10.1007/s11136-012-0150-6. Epub 2012 Mar 11.
This study seeks to establish the construct validity of Health Utilities Index Mark 3 (HUI3)--a health state utility measure--in a Nigerian population of hypertensive patients.
A descriptive cross-sectional study was conducted in a population of hypertensive patients in two tertiary hospitals located in South-Eastern Nigeria. A priori hypotheses were tested to establish construct validity.
A total of 384 participants were interviewed. Hypertensive patients with stroke or coronary heart disease (CHD) had a lower overall utility value compared to those with hypertension alone. There was a significant difference in group means of 0.53 (95 % confidence interval of 0.44-0.62); t = 11.8, p < 0.01, between participants that had hypertension alone and participants with hypertension and stroke. Also, there was a significant difference in group means of 0.44 (95 % confidence interval of 0.34-0.56); t = 8.2, p < 0.01, between participants that had hypertension alone and participants with hypertension and CHD. Generally, there was a significant health-related quality of life deficit among patients with severe clinical variables compared to those with milder clinical variables.
HUI3 demonstrated constructed validity among a population of Nigerian patients with high blood pressure.
本研究旨在确定健康效用指数 3 版（HUI3）——一种健康状况效用衡量指标——在尼日利亚高血压患者人群中的结构效度。
在尼日利亚东南部的两家三级医院的高血压患者人群中进行了一项描述性的横断面研究。进行了预先假设检验以确定结构效度。
共对 384 名参与者进行了访谈。患有中风或冠心病（CHD）的高血压患者的总体效用值低于单纯患有高血压的患者。组间均值差异为 0.53（95%置信区间为 0.44-0.62）；t=11.8，p<0.01，患有单纯高血压的参与者与患有高血压和中风的参与者之间存在显著差异。此外，患有单纯高血压的参与者与患有高血压和 CHD 的参与者之间的组间均值差异为 0.44（95%置信区间为 0.34-0.56）；t=8.2，p<0.01。一般来说，与临床症状较轻的患者相比，严重临床变量的患者的健康相关生活质量存在显著缺陷。
HUI3 在尼日利亚高血压患者人群中表现出了结构效度。
