评价一种超氧化物歧化酶模拟物 Mn 配合物在激活的巨噬细胞中的抗氧化特性。
Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages.
机构信息
Ecole Normale Supérieure, Département de chimie, Paris, France.
出版信息
Dalton Trans. 2012 Jun 7;41(21):6399-403. doi: 10.1039/c2dt12479c. Epub 2012 Mar 12.
PMID:22407398
Abstract
SOD-mimics are small complexes that reproduce the activity of superoxide dismutases, natural proteins that catalytically dismutate the superoxide anion. Activated macrophages, which produce ROS and RNS fluxes, constitute a relevant model to challenge antioxidant activity in a cellular context and were used to test a Mn-complex which was shown to efficiently alter the flow of O(2)(-), ONOO(-) and H(2)O(2).
摘要
超氧化物歧化酶模拟物是小的复合物，可复制超氧化物歧化酶的活性，超氧化物歧化酶是催化超氧阴离子歧化的天然蛋白质。产生 ROS 和 RNS 流的活化巨噬细胞构成了一个相关的模型，可以在细胞环境中挑战抗氧化活性，并被用于测试一种 Mn 配合物，该配合物被证明可以有效地改变 O(2)(-)、ONOO(-)和 H(2)O(2)的流动。
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