Department of Chemistry, LMU Muenchen, Butenandtstr. 5-13, 81377 Muenchen, Germany.
Org Biomol Chem. 2012 Apr 28;10(16):3210-8. doi: 10.1039/c2ob07058h. Epub 2012 Mar 12.
The aza-Morita-Baylis-Hillman (azaMBH) reaction has been studied for electronically and sterically deactivated Michael acceptors. It is found that electronically deactivated systems can be converted with electron-rich phosphanes and pyridines as catalysts equally well. For sterically deactivated systems clearly better catalytic turnover can be achieved with pyridine catalysts. This is in accordance with the calculated affinities of the catalysts towards different Michael-acceptors.
氮杂-Morita-Baylis-Hillman (azaMBH) 反应已经在电子和空间位阻上失活的迈克尔受体中进行了研究。研究发现，电子去活化体系同样可以用富电子膦和吡啶作为催化剂进行转化。对于空间位阻较大的体系，吡啶催化剂显然可以实现更好的催化周转率。这与计算出的催化剂对不同迈克尔受体的亲和力一致。
