Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9070, USA.
Pharmacol Rev. 2012 Apr;64(2):238-58. doi: 10.1124/pr.111.005108. Epub 2012 Mar 8.
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases. In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics. The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development.
脑源性神经营养因子（BDNF）是中枢神经系统（CNS）中最普遍的生长因子。它对 CNS 的发育和神经元可塑性至关重要。由于 BDNF 在大脑的发育和可塑性中发挥着关键作用，因此它广泛涉及精神疾病。这篇综述总结了临床和临床前证据，证明这种普遍存在的生长因子参与了重度抑郁症、精神分裂症、成瘾、雷特综合征以及其他精神和神经发育性疾病。此外，该综述还讨论了 BDNF 在目前用于治疗这些疾病的药物治疗机制中的作用，如抗抑郁药和抗精神病药。该综述还涵盖了对 BDNF 模拟物等实验疗法的批评，并讨论了 BDNF 作为未来药物开发靶点的价值。
