Worni Mathias, Østbye Truls, Gandhi Mihir, Rajgor Dimple, Shah Jatin, Shah Anand, Pietrobon Ricardo, Jacobs Danny O, Guller Ulrich
Research on Research Group, Department of Surgery, Duke University Medical Center, Durham, NC, USA.
World J Surg. 2012 Jul;36(7):1527-33. doi: 10.1007/s00268-012-1550-z.
The "weekend effect" is defined as increased morbidity and mortality for patients admitted on weekends compared with weekdays. It has been observed for several diseases, including myocardial infarction and renal insufficiency; however, it has not yet been investigated for laparoscopic appendectomy in acute appendicitis-one of the most prevalent surgical diagnoses.
The present study is based on the Nationwide Inpatient Sample (NIS) from 1999 to 2008. The following outcomes were compared between patients undergoing laparoscopic appendectomy for acute appendicitis admitted on weekdays versus weekends: severity of appendicitis, intraoperative and postoperative complications, conversion rate, in-hospital mortality, and length of hospital stay. Unadjusted and risk-adjusted generalized linear regression analyses were performed.
Overall, 151,774 patients were included, mean age was 39.6 years, 52.6% (n = 79,801) were male, and 25.3% (n = 38,317) were admitted on weekends. After risk adjustment, the conversion rate was lower [odds ratio (OR): 0.94, p = 0.004, number needed to harm (NNH): 244], whereas pulmonary complications (OR: 1.12, p = 0.028, NNH: 649) and reoperations (OR: 1.21, p = 0.013, NNH: 1,028) were slightly higher on weekends than on weekdays. Overall postoperative complications (OR: 1.03, p = 0.24), mortality (OR: 1.37, p = 0.075) and length of hospital stay (mean on weekday: 2.00 days, weekends: 2.01 days, p = 0.29) were not statistically different.
The present investigation provides evidence that no clinically significant "weekend effect" for patients undergoing laparoscopic appendectomy exists. Therefore, hospital or staffing policy changes are not justified based on the findings from this large national study.
“周末效应”定义为与工作日入院的患者相比,周末入院患者的发病率和死亡率增加。在包括心肌梗死和肾功能不全在内的几种疾病中已观察到这种现象;然而,对于急性阑尾炎(最常见的外科诊断之一)行腹腔镜阑尾切除术,尚未对此进行研究。
本研究基于1999年至2008年的全国住院患者样本(NIS)。比较了工作日与周末因急性阑尾炎行腹腔镜阑尾切除术患者的以下结局:阑尾炎严重程度、术中及术后并发症、转化率、住院死亡率和住院时间。进行了未调整和风险调整的广义线性回归分析。
总体而言,纳入151,774例患者,平均年龄39.6岁,52.6%(n = 79,801)为男性,25.3%(n = 38,317)在周末入院。风险调整后,转化率较低[比值比(OR):0.94,p = 0.004,伤害所需人数(NNH):244],而肺部并发症(OR:1.12,p = 0.028,NNH:649)和再次手术(OR:1.21,p = 0.013,NNH:1,028)在周末略高于工作日。总体术后并发症(OR:1.03,p = 0.24)、死亡率(OR:1.37,p = 0.075)和住院时间(工作日平均:2.00天,周末:2.01天,p = 0.29)无统计学差异。
本研究提供的证据表明,对于行腹腔镜阑尾切除术的患者不存在临床上显著的“周末效应”。因此,基于这项大型全国性研究的结果,医院或人员配置政策的改变是不合理的。