Department of Molecular Pathology and Neuropathology, Medical University Lodz, Lodz, Poland.
Adv Exp Med Biol. 2012;724:143-53. doi: 10.1007/978-1-4614-0653-2_12.
Kuru disease is linked with the name of D. Carleton Gajdusek and he was the first to show that this human neurodegenerative disease can be transmitted to chimpanzees and subsequently classified as a transmissible spongiform encephalopathy (TSE), or slow unconventional virus disease. It was first reported to Western world in 1957 by Gajdusek and Vincent Zigas,(1,2) and in 1975 a complete bibliography of kuru was published by Alpers et al.(3) "Kuru" in the Fore language in Papua New Guinea means to shiver from fever and cold. The disease has been found to spread through ritualistic cannibalism and is an invariably fatal cerebellar ataxia accompanied by tremor, choreiform and athetoid movements. Neuropathologically, kuru is characterized by the presence of amyloid "kuru" plaques.
库鲁病与 D. 卡勒顿·盖杜谢克的名字有关，他是第一个证明这种人类神经退行性疾病可以传播给黑猩猩，并随后被归类为传染性海绵状脑病（TSE）或缓慢非常规病毒病的人。1957 年，盖杜谢克和文森特·齐加斯首次向西方世界报告了这种疾病，(1,2) 1975 年，阿尔珀斯等人出版了库鲁病的完整参考文献。(3) 在巴布亚新几内亚的 Fore 语言中，“kuru”的意思是因发烧和寒冷而颤抖。这种疾病已被发现通过仪式性食人传播，是一种不可避免的致命小脑共济失调，伴有震颤、舞蹈样和手足徐动症运动。神经病理学上，库鲁病的特征是存在淀粉样“kuru”斑块。
