Liberski Paweł P
Dept. Molecular Pathology, Medical University Lodz, Czechoslowacka Street 8/10, PL 92-216 Lodz, Poland.
Folia Neuropathol. 2009;47(2):114-37.
Kuru, the first human transmissible spongiform encephalopathy, was transmitted to chimpanzees by D. Carleton Gajdusek (1923-2008). In this review, I briefly summarize the history of this seminal discovery alongside its epidemiology, clinical picture, neuropathology and molecular genetics. The discovery of kuru opened new windows into the realms of human medicine and was instrumental in the later transmission of Creutzfeldt-Jakob disease as well as the prediction that bovine spongiform encephalopathy would be transmitted to humans. It was one of the greatest discoveries in biomedical sciences of the 20th century.
库鲁病是首例人类可传播性海绵状脑病，由D. 卡尔顿·盖杜谢克（1923 - 2008）传播给黑猩猩。在这篇综述中，我简要概述了这一开创性发现的历史，以及其流行病学、临床表现、神经病理学和分子遗传学。库鲁病的发现为人类医学领域打开了新的窗口，并在后来克雅氏病的传播以及牛海绵状脑病会传播给人类的预测中发挥了重要作用。它是20世纪生物医学科学领域最伟大的发现之一。
